2410402-75-2

2410402-75-2 structure

Name: Carbonic anhydrase inhibitor 14
Chemical Name: Carbonic anhydrase inhibitor 14
CAS Number: 2410402-75-2
Molecular Formula: C₁₈H₁₇N₇O₂S
Molecular Weight: 395.44
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2022-08-31 20:17:27
Modify Date: 2024-01-06 21:47:11
Carbonic anhydrase inhibitor 14 (Compound 8b) is a carbonic anhydrase (CA) inhibitor with Ki values of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 14 can also inhibit CDK2 with an IC50 of 20.3 μM. Carbonic anhydrase inhibitor 14 shows antitumor activity[1].

Name	Carbonic anhydrase inhibitor 14

Description	Carbonic anhydrase inhibitor 14 (Compound 8b) is a carbonic anhydrase (CA) inhibitor with Ki values of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 14 can also inhibit CDK2 with an IC50 of 20.3 μM. Carbonic anhydrase inhibitor 14 shows antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK2:20.3 μM (IC50) hCA I:1203 nM (Ki) hCA II:99.7 nM (Ki) hCA IX:9.4 nM (Ki) hCA XII:27.7 nM (Ki)
References	[1]. Said MA, et al. Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation. Eur J Med Chem. 2020 Mar 1;189:112019.

Molecular Formula	C₁₈H₁₇N₇O₂S
Molecular Weight	395.44