1186049-44-4
1186049-44-4 structure
- Name: DDO-02005
- Chemical Name: DDO-02005
- CAS Number: 1186049-44-4
- Molecular Formula: C21H27Cl2N3O2
- Molecular Weight: 424.36
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2022-07-01 14:04:26
- Modify Date: 2024-01-09 11:56:57
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DDO-02005 is a potent Kv1.5 potassium channel inhibitor with an IC50 value of 0.72 μM. DDO-02005 has good anti-atrial fibrillation (AF) effect in CaCl2-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine[1].
| Name | DDO-02005 |
|---|
| Description | DDO-02005 is a potent Kv1.5 potassium channel inhibitor with an IC50 value of 0.72 μM. DDO-02005 has good anti-atrial fibrillation (AF) effect in CaCl2-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.72 μM (Kv1.5 potassium channel)[1] |
| In Vivo | DDO-02005 (0.1, 1, 3, 9 mg/kg; IV, single dosage) effectively combat the arrhythmogenic toxicity of aconitine in rats[1]. Pharmacokinetic Parameters of DDO-02005 in Sprague-Dawley rats[1]. IV (1 mg/kg) PO (1.25 mg/kg) t1/2 (h) 3.23 ± 1.07 6.25 ± 2.40 Cmax (μg/L) 90.23 ± 28.83 1.27 ± 0.40 AUC0-t (μg/L·h) 178.42 ± 39.33 4.41 ± 0.69 CL (L/h/kg) 5.83 ± 1.44 36.51 ± 2.54 |
| References |
| Molecular Formula | C21H27Cl2N3O2 |
|---|---|
| Molecular Weight | 424.36 |