2738688-82-7
2738688-82-7 structure
- Name: SW-101
- Chemical Name: SW-101
- CAS Number: 2738688-82-7
- Molecular Formula: C18H19N3O3
- Molecular Weight: 325.368
- Create Date: 2022-09-02 16:48:36
- Modify Date: 2023-02-09 22:32:23
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SW-101 (SW101) is a potent, selective HDAC6 inhibitor with IC50 of 0.7 nM, >200-fold selectivity over HDAC1/2/3.SW-101 possesses excellent HDAC6 potency and selectivity, together with markedly improved metabolic stability and druglike properties compared to SW-100.SW-101 treatment elevates the impaired level of acetylated α-tubulin in the distal sciatic nerve, counteracts progressive motor dysfunction, and ameliorates neuropathic symptoms in a CMT2A mouse model bearing mutant MFN2.
| Name | SW-101 |
|---|
| Description | SW-101 (SW101) is a potent, selective HDAC6 inhibitor with IC50 of 0.7 nM, >200-fold selectivity over HDAC1/2/3.SW-101 possesses excellent HDAC6 potency and selectivity, together with markedly improved metabolic stability and druglike properties compared to SW-100.SW-101 treatment elevates the impaired level of acetylated α-tubulin in the distal sciatic nerve, counteracts progressive motor dysfunction, and ameliorates neuropathic symptoms in a CMT2A mouse model bearing mutant MFN2. |
|---|---|
| References | 1. Sida Shen, et al. J Med Chem. 2021 Apr 22;64(8):4810-4840. |
| Molecular Formula | C18H19N3O3 |
|---|---|
| Molecular Weight | 325.368 |