2305750-23-4
2305750-23-4 structure
- Name: IM-250
- Chemical Name: IM-250
- CAS Number: 2305750-23-4
- Molecular Formula: C20H19F2N3O2S2
- Molecular Weight: 435.51
- Create Date: 2022-07-01 19:25:55
- Modify Date: 2024-01-04 15:31:13
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IM-250 is a potent HSV-1 helicase primase inhibitor, inhibits HSV-1 replication with IC50 of 20 nM (clinical isolate of HSV-1).IM-250 dispalys similar IC50 values (20-30 nM) against ACV-resistant HSV-1 clinical isolates 2 and 3 and ACV-resistant HSV-2 clinical isolates 7 and 8.IM-250 exhibits a broad therapeutic window against HSV-1 in vitro with pronounced higher SI values as obtained for acyclovir (ACV).IM-250 shows in vivo efficacy and attenuates viral burden in HSV-1 infection mouse model.
| Name | IM-250 |
|---|
| Description | IM-250 is a potent HSV-1 helicase primase inhibitor, inhibits HSV-1 replication with IC50 of 20 nM (clinical isolate of HSV-1).IM-250 dispalys similar IC50 values (20-30 nM) against ACV-resistant HSV-1 clinical isolates 2 and 3 and ACV-resistant HSV-2 clinical isolates 7 and 8.IM-250 exhibits a broad therapeutic window against HSV-1 in vitro with pronounced higher SI values as obtained for acyclovir (ACV).IM-250 shows in vivo efficacy and attenuates viral burden in HSV-1 infection mouse model. |
|---|---|
| References | 1. Uhlig N, et al. Antiviral Res. 2021 Nov;195:105190. |
| Molecular Formula | C20H19F2N3O2S2 |
|---|---|
| Molecular Weight | 435.51 |