1933533-18-6

1933533-18-6 structure

Name: SPT-IN-1
Chemical Name: SPT Imidazopyridine 1
CAS Number: 1933533-18-6
Molecular Formula: C₂₂H₂₄N₂O₃
Molecular Weight: 364.44
Catalog: Research Areas Metabolic Disease
Create Date: 2022-05-06 18:40:16
Modify Date: 2024-01-16 13:51:00
SPT-IN-1 (compound 1) is an orally active and potent SPT (serine palmitoyl transferase) inhibitor, with an IC50 of 5.19 nM for hSPT1. SPT-IN-1 can be used for type 2 diabetes and dyslipidemia research[1].

Name	SPT Imidazopyridine 1
Synonyms	MFCD31579859 [4-(6-Heptanoylimidazo[1,2-a]pyridin-8-yl)phenyl]acetic acid Benzeneacetic acid, 4-[6-(1-oxoheptyl)imidazo[1,2-a]pyridin-8-yl]- 4-[6-(1-Oxoheptyl)imidazo[1,2-a]pyridin-8-yl]benzeneacetic acid

Description	SPT-IN-1 (compound 1) is an orally active and potent SPT (serine palmitoyl transferase) inhibitor, with an IC50 of 5.19 nM for hSPT1. SPT-IN-1 can be used for type 2 diabetes and dyslipidemia research[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	IC50: 5.19 nM (hSPT1)[1]
In Vitro	SPT-IN-1 (compound 1) exhibits a dose-dependent inhibition of C14-serine incorporation into ceramide in MCF-7 cells, with EC50 of 0.98 μM[1].
In Vivo	SPT-IN-1 (compound 1) (Sprague Dawley rats, 0-60 mg/kg, Orally, twice daily for 7 days) dose-dependently reduces plasma ceramides, reduces triglycerides and raises HDL in cholesterol/cholic acid fed rats[1].
References	[1]. Genin MJ, et al. Imidazopyridine and Pyrazolopiperidine Derivatives as Novel Inhibitors of Serine Palmitoyl Transferase. J Med Chem. 2016;59(12):5904-5910.