1793080-72-4

1793080-72-4 structure

Name: VX-150
Chemical Name: VX-150
CAS Number: 1793080-72-4
Molecular Formula: C₂₁H₁₇F₄N₂O₇P
Molecular Weight: 516.34
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2021-10-30 17:39:42
Modify Date: 2024-01-05 18:38:56
VX-150 is an orally active, highly selective NaV1.8 inhibitor. VX-150 has the potential for various pain indications research[1].

Name	VX-150
Synonyms	(4-(2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxo-1l4,2l5-pyridin-1-yl)methyldihydrogenphosphate

Description	VX-150 is an orally active, highly selective NaV1.8 inhibitor. VX-150 has the potential for various pain indications research[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
Target	Nav1.8
In Vitro	VX-150 is an orally bioavailable pro-drug that rapidly converts into its active moiety, which is a highly selective inhibitor of NaV1.8 relative to the other sodium channel subtypes (>400-fold)[1].
References	[1]. Hemme J Hijma, et al. A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Pharmacodynamic Effects of VX-150, a Highly Selective NaV1.8 Inhibitor, in Healthy Male Adults. Pain Med. 2021 Aug 6;22(8):1814-1826.