Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: adrenaline sulfate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

52455-32-0

52455-32-0 structure

Name: adrenaline sulfate
Chemical Name: Ethyl 3-ethyl-2-methyl-4-oxo-2-cyclohexene-1-carboxylate
CAS Number: 52455-32-0
Molecular Formula: C₁₂H₁₈O₃
Molecular Weight: 210.270
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2021-09-13 15:07:50
Modify Date: 2024-01-27 19:08:55
Adrenaline sulfate is a orally active hormone secreted by the medulla of the adrenal glands. Adrenaline sulfate is an α-adrenergic and β-adrenergic receptor agonist. Adrenaline sulfate can be used in the treatment of anaphylaxis. Adrenaline sulfate has the potential for the research of cardiac arrest[1][2][3][4].

Name	Ethyl 3-ethyl-2-methyl-4-oxo-2-cyclohexene-1-carboxylate
Synonyms	2-Cyclohexene-1-carboxylic acid, 3-ethyl-2-methyl-4-oxo-, ethyl ester MFCD00001579 Ethyl 3-ethyl-2-methyl-4-oxo-2-cyclohexene-1-carboxylate Ethyl 3-ethyl-2-methyl-4-oxocyclohex-2-ene-1-carboxylate

Description	Adrenaline sulfate is a orally active hormone secreted by the medulla of the adrenal glands. Adrenaline sulfate is an α-adrenergic and β-adrenergic receptor agonist. Adrenaline sulfate can be used in the treatment of anaphylaxis. Adrenaline sulfate has the potential for the research of cardiac arrest[1][2][3][4].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
Target	Human Endogenous Metabolite
In Vivo	Adrenaline sulfate (0.75, 1.5, 3 mg/kg; i.p.) exerts oxidative and nitrative stress in rats, increased damage to lipids and proteins, and damage of cardiomyocytes and cytogenetic damage in rats[2]. Adrenaline sulfate (0.02, 0.03 mg/kg) increases ABP’s and to some extent also CePP, but significantly decreases organ and brain perfusion in adult pigs[3]. Adrenaline sulfate (0.1 mg/kg; s.c.) enhances memory in young adult rats, in part, by increasing blood glucose levels needed to modulate memory[6]. Animal Model: 220-280 g, 18 weeks Wistar rats[2] Dosage: 0.75, 1.5, 3 mg/kg Administration: IP Result: Induced a significant rise in CAT activity, MDA level, PCC, NO2−, and 3-NT and a significant decrease in SOD activity, and exerted an increase in total activity of LDH, LDH1, and LDH2 isoenzymes. Animal Model: 24-25 month male Fischer-344 rats[6] Dosage: 0.1 mg/kg Administration: S.c. Result: Enhanced memory in young adult rats, in part, by increasing blood glucose levels needed to modulate memory.
References	[1]. McLean-Tooke AP, et al. Adrenaline in the treatment of anaphylaxis: what is the evidence? BMJ. 2003 Dec 6;327(7427):1332-5. [2]. Radaković M, et al. Nitroso-Oxidative Stress, Acute Phase Response, and Cytogenetic Damage in Wistar Rats Treated with Adrenaline. Oxid Med Cell Longev. 2018 Nov 21;2018:1805354. [3]. Hardig BM, et al. Physiologic effect of repeated adrenaline (epinephrine) doses during cardiopulmonary resuscitation in the cath lab setting: A randomised porcine study. Resuscitation. 2016 Apr;101:77-83. [4]. Callaway CW. Epinephrine for cardiac arrest. Curr Opin Cardiol. 2013 Jan;28(1):36-42. [5]. Simons FE, et al. First-aid treatment of anaphylaxis to food: focus on epinephrine. J Allergy Clin Immunol. 2004 May;113(5):837-44. [6]. Morris KA, et al. Epinephrine and glucose modulate training-related CREB phosphorylation in old rats: relationships to age-related memory impairments. Exp Gerontol. 2013 Feb;48(2):115-27.

Density	1.0±0.1 g/cm3
Boiling Point	301.3±42.0 °C at 760 mmHg
Molecular Formula	C₁₂H₁₈O₃
Molecular Weight	210.270
Flash Point	129.0±27.9 °C
Exact Mass	210.125595
LogP	2.29
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.471

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