133514-43-9
133514-43-9 structure
- Name: Exendin Fragment 9-39
- Chemical Name: Exendin (9-39)
- CAS Number: 133514-43-9
- Molecular Formula: C149H234N40O47S
- Molecular Weight: 3369.757
- Catalog: Biochemical Peptide
- Create Date: 2018-05-17 08:00:00
- Modify Date: 2024-01-02 16:20:16
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Exendin (9-39) is a specific and competitive glucagon-like peptide-1 receptor antagonist.
| Name | Exendin (9-39) |
|---|---|
| Synonyms |
Exendin 9-39
Exendin(9-39)amide L-Serinamide, L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-alp 
ha-glutamyl-L-tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl- UNII-5313W10MYT Exendin-3 (9-39) amide L-α-Aspartyl-L-leucyl-L-seryl-L-lysyl-L-glutaminyl-L-methionyl-L-α-glutamyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-arginyl-L-leucyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L- tryptophyl-L-leucyl-L-lysyl-L-asparaginylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-serinamide Exendin 3 (heloderma horridum),1-de-L-histidine-2-de-L-serine-3-de-L-aspartic acid-4-deglycine-5-de-L-threonine-6-de-L-phenylalanine-7-de-L-threonine-8-de-L-serine MFCD00283195 |
| Description | Exendin (9-39) is a specific and competitive glucagon-like peptide-1 receptor antagonist. |
|---|---|
| Related Catalog | |
| In Vitro | GLP-1 plays a role in the control of fasting glucose. Exendin-(9-39), a truncated form of the GLP-1 agonist exendin-4, is a specific GLP-1 receptor antagonist in mice and humans. Exendin (9-39) significantly inhibits amino acid-stimulated insulin secretion in pancreatic islets isolated from neonates with KATPHI[1]. |
| In Vivo | Insulin-to-glucose ratios are significantly lower during Exendin (9-39) infusion compared with vehicle[1]. Continuous subcutaneous infusion of exendin-(9-39) significantly raises fasting blood glucose levels in SUR-1 −/− mice without affecting glucose tolerance or insulin sensitivity[2]. |
| Animal Admin | Mice: Alzet miniosmotic pumps are implanted subcutaneously to deliver exendin (9-39) at a rate of 150 pmol/kg/min or vehicle (0.9% NaCl, 1% bovine serum albumin) for 2 weeks[2]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C149H234N40O47S |
| Molecular Weight | 3369.757 |
| Exact Mass | 3367.687012 |
| PSA | 1415.58000 |
| LogP | -5.88 |
| Index of Refraction | 1.671 |
| Storage condition | -20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | F+ |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |