194468-36-5
194468-36-5 structure
- Name: BMS 710485
- Chemical Name: Vinflunine ditartrate
- CAS Number: 194468-36-5
- Molecular Formula: C53H66F2N4O20
- Molecular Weight: 1117.103
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
- Create Date: 2021-01-10 11:25:39
- Modify Date: 2024-01-12 11:47:18
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Vinflunine ditartrate is the first fluorinated microtubule inhibitor belonging to the Vinca alkaloids family. Vinflunine ditartrate has anti-angiogenic, vascular-disrupting and anti-metastatic activities. Vinflunine ditartrate can be used for the research of transitional cell carcinoma of the urothelial tract, non-small cell lung cancer, and carcinoma of the breast[1][2].
| Name | Vinflunine ditartrate |
|---|---|
| Synonyms |
Vinflunine ditartrate
Javlor (2R,3R)-2,3-Dihydroxysuccinic acid - methyl (2β,3β,4β,5α,12β,19α)-4-acetoxy-15-[(12S,14S,16R)-16-(1,1-difluoroethyl)-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.03,11.04,9 ]octadeca-3(11),4,6,8-tetraen-12-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate (2:1) Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16 ;-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-, compd. with (2R,3R)-2,3-dihydroxybutanedioic acid (1:2) |
| Description | Vinflunine ditartrate is the first fluorinated microtubule inhibitor belonging to the Vinca alkaloids family. Vinflunine ditartrate has anti-angiogenic, vascular-disrupting and anti-metastatic activities. Vinflunine ditartrate can be used for the research of transitional cell carcinoma of the urothelial tract, non-small cell lung cancer, and carcinoma of the breast[1][2]. |
|---|---|
| Related Catalog | |
| Target |
microtubule[1] |
| In Vitro | Vinflunine (0.01-10 μM; 45 min) induces a rapid change in endothelial cell shape: cells retracted and assumed a rounded morphology[2]. Vinflunine (0.01-10 μM; 1 h) disrupts newly formed capillary-like structures[2]. Vinflunine (0.01-10 μM; 1 h) inhibits endothelial cell motility, with an IC50 of 0.71 μM[2]. Vinflunine (0.001-10 μM; 1-72 h) inhibits endothelial cell proliferation in vitro[2]. |
| In Vivo | Vinflunine (0.08-20 mg/kg; i.v.) reduces the number of experimental liver metastases by human LS174T colon cancer cells[2]. Vinflunine (0.63-5 mg/kg; i.v. before and 2 d after Matrigel implantation) inhibits the bFGF-induced angiogenic response in mice in a dose-dependent manner[2]. Animal Model: Female athymic nude mice (BALB/c/Ola/Hsd-nu) were implanted LS174T cells[2] Dosage: 0.08, 0.16, 1.25, 5, 10, 20 mg/kg Administration: I.v. on days 4, 7, 11, 14, 18 and 21 after tumour cell implantation Result: Induced a dose-dependent reduction in the number of metastatic foci at the surface of the liver and was well tolerated. |
| References |
| Molecular Formula | C53H66F2N4O20 |
|---|---|
| Molecular Weight | 1117.103 |
| Exact Mass | 1116.423828 |