105925-39-1

105925-39-1 structure

Name: Tubulin inhibitor 6
Chemical Name: Tubulin inhibitor 6
CAS Number: 105925-39-1
Molecular Formula: C₂₀H₁₄ClNO₂S
Molecular Weight: 367.85
Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
Create Date: 2020-06-01 22:24:23
Modify Date: 2024-01-12 00:24:19
Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC50 of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC50 of 840 nM[1].

Name	Tubulin inhibitor 6
Synonyms	MFCD01245092

Description	Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC50 of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC50 of 840 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	IC50: 0.87 μM (tubulin polymerization)[1]
In Vitro	Tubulin inhibitor 6 displays submicromolar antiproliferative activity[1].
References	[1]. Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63.

Molecular Formula	C₂₀H₁₄ClNO₂S
Molecular Weight	367.85

Hazard Codes	Xi