740816-86-8

740816-86-8 structure

Name: O-Desmethyl Midostaurin
Chemical Name: O-Desmethyl Midostaurin
CAS Number: 740816-86-8
Molecular Formula: C₃₄H₂₈N₄O₄
Molecular Weight: 556.61
Catalog: Signaling Pathways Epigenetics PKC
Create Date: 2020-06-01 18:06:03
Modify Date: 2024-01-10 10:04:10
O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.

Name	O-Desmethyl Midostaurin

Description	O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> TGF-beta/Smad >> PKC
Target	IC50: active metabolite of Midostaurin[1]
References	[1]. Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors.Blood. 2006 Nov 15;108(10):3477-83.