DC Chemicals Limited
China
Product Name: DHODH-IN-9
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Purity: 98.0%
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1644156-41-1

1644156-41-1 structure

1644156-41-1 structure

Name: DHODH-IN-9
Chemical Name: DHODH-IN-9
CAS Number: 1644156-41-1
Molecular Formula: C₂₁H₂₃FN₄O
Molecular Weight: 366.43
Catalog: Signaling Pathways Anti-infection Influenza Virus
Create Date: 2020-04-09 15:38:14
Modify Date: 2024-01-17 01:11:30
DHODH-IN-9 (Compound 10k) is an azine-bearing analogue and is a human dihydroorotate dehydrogenase inhibitor. DHODH-IN-9 has antiviral effect with a pMIC50 of 7.4[1].

Name	DHODH-IN-9

Description	DHODH-IN-9 (Compound 10k) is an azine-bearing analogue and is a human dihydroorotate dehydrogenase inhibitor. DHODH-IN-9 has antiviral effect with a pMIC50 of 7.4[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase
Target	pMIC50: 7.4 (DHODH)[1]
In Vitro	DHODH-IN-9 (Compound 10k) is a corresponding pyridazine homologue from 3-chloro-6-cyclopropylpyridazine. With few variations, the pattern of antiviral effect for analogues featuring a 5-cyclopylpyridine is somehow mirroring the one seen for the 5-ethylpyrimidyl bearing homologues. DHODH-IN-9 (Compound 10k) is a good antiviral of this group of analogue[1].
References	[1]. Lucas-Hourani M, et al.Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).J Med Chem. 2015 Jul 23;58(14):5579-98.

Molecular Formula	C₂₁H₂₃FN₄O
Molecular Weight	366.43