1184661-33-3
1184661-33-3 structure
- Name: DSP-6952 hydrobromide
- Chemical Name: DSP-6952 hydrobromide
- CAS Number: 1184661-33-3
- Molecular Formula: C21H32BrClN4O5
- Molecular Weight: 535.864
- Create Date: 2020-01-20 15:00:56
- Modify Date: 2023-01-18 19:05:28
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DSP-6952 is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c; enhances gastric motility and causes colonic giant migrating contractions (GMCs) associated with defecation in conscious dogs, having ED50 value for inducing GMCs of 1.56 mg/kg; rapidly increases fecal wet weight without increasing fluid content in mice (1-10 mg/kg, p.o.).
| Name | DSP-6952 hydrobromide |
|---|
| Description | DSP-6952 is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c; enhances gastric motility and causes colonic giant migrating contractions (GMCs) associated with defecation in conscious dogs, having ED50 value for inducing GMCs of 1.56 mg/kg; rapidly increases fecal wet weight without increasing fluid content in mice (1-10 mg/kg, p.o.). |
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| References | References 1. Mine Y, et al. Eur J Pharmacol. 2018 Feb 9;826:123-132. 2. Tsubouchi T, et al. Eur J Pharmacol. 2018 Mar 1;826:96-105. View Related Products by Target 5-HT Receptor |
| Molecular Formula | C21H32BrClN4O5 |
|---|---|
| Molecular Weight | 535.864 |