Name | PI3K-IN-16 |
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Description | PI3K-IN-16 is a potent and selective, orally bioavailable PI3Kβ and PI3Kδ inhibitor with cell IC50 of 12 nM (in PTEN null MDA-MB-468 cell) and 47 nM (in Jeko-1 B-cell), respectively; exhibits no significant activity on PI3Kα; shows profound pharmacodynamic modulation of AKT phosphorylation, excellent tumour growth inhibition in a mouse PTEN-deficient PC3 prostate tumour xenograft. |
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References | References 1. Barlaam B, et al. Bioorg Med Chem Lett. 2016 May 1;26(9):2318-23. View Related Products by Target PI3K |
Molecular Formula | C25H26FN3O5 |
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Molecular Weight | 467.497 |