939390-99-5

939390-99-5 structure

Name: BMS 795311
Chemical Name: N-{(1R)-1-[3-(Cyclopropyloxy)-4-fluorophenyl]-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl}-4-fluoro-3-(trifluoromethyl)benzamide
CAS Number: 939390-99-5
Molecular Formula: C₃₃H₂₃F₁₀NO₃
Molecular Weight: 671.525
Catalog: Signaling Pathways Metabolic Enzyme/Protease CETP
Create Date: 2020-01-20 16:29:57
Modify Date: 2024-01-08 17:39:14
BMS-795311 is a potent and orally available CETP inhibitor with IC50 of 3.8 nM, inhibits cholesteryl ester (CE) transfer with IC50 of 0.22 uM; inhibits CE transfer activity at an oral dose of 1 mg/kg in human CETP/apoB-100 dual transgenic mice and increased HDL cholesterol content and size comparable to Torcetrapib in moderately-fat fed hamsters.

Name	N-{(1R)-1-[3-(Cyclopropyloxy)-4-fluorophenyl]-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl}-4-fluoro-3-(trifluoromethyl)benzamide
Synonyms	N-{(1R)-1-[3-(Cyclopropyloxy)-4-fluorophenyl]-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl}-4-fluoro-3-(trifluoromethyl)benzamide Benzamide, N-[(1R)-1-[3-(cyclopropyloxy)-4-fluorophenyl]-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)-

Description	BMS-795311 is a potent and orally available CETP inhibitor with IC50 of 3.8 nM, inhibits cholesteryl ester (CE) transfer with IC50 of 0.22 uM; inhibits CE transfer activity at an oral dose of 1 mg/kg in human CETP/apoB-100 dual transgenic mice and increased HDL cholesterol content and size comparable to Torcetrapib in moderately-fat fed hamsters.
References	References 1. Qiao JX, et al. J Med Chem. 2015 Nov 25;58(22):9010-26. View Related Products by Target CETP