2109805-83-4
2109805-83-4 structure
- Name: UMB-136
- Chemical Name: N-Cyclohexyl-2-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methoxyphenyl]imidazo[1,2-a]pyrazin-3-amine
- CAS Number: 2109805-83-4
- Molecular Formula: C24H27N5O2
- Molecular Weight: 417.504
- Catalog: Signaling Pathways Anti-infection HIV
- Create Date: 2020-01-11 19:11:44
- Modify Date: 2023-01-18 16:13:22
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A novel bromodomain BRD4 inhibitor that significantly induces HIV-1 reactivation; dramatically reversed HIV-1 latency at both low (2.5 uM) and high (5 uM) doses in multiple cell models of HIV-1 latency through promoting Tat-dependent transcriptional elongation and Tat-P-TEFb association; enhances the latency-reversing effects of PKC agonists (prostratin, bryostatin-1) in CD8-depleted PBMCs containing latent viral reservoirs.
| Name | N-Cyclohexyl-2-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methoxyphenyl]imidazo[1,2-a]pyrazin-3-amine |
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| Synonyms |
N-Cyclohexyl-2-[4-(3,5-dimethyl-1,2-oxazol-4-yl)-2-methoxyphenyl]imidazo[1,2-a]pyrazin-3-amine
Imidazo[1,2-a]pyrazin-3-amine, N-cyclohexyl-2-[4-(3,5-dimethyl-4-isoxazolyl)-2-methoxyphenyl]- |
| Description | A novel bromodomain BRD4 inhibitor that significantly induces HIV-1 reactivation; dramatically reversed HIV-1 latency at both low (2.5 uM) and high (5 uM) doses in multiple cell models of HIV-1 latency through promoting Tat-dependent transcriptional elongation and Tat-P-TEFb association; enhances the latency-reversing effects of PKC agonists (prostratin, bryostatin-1) in CD8-depleted PBMCs containing latent viral reservoirs. |
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| References | References 1. Huang H, et al. Front Microbiol. 2017 Jun 7;8:1035. View Related Products by Target Bromodomain |
| Density | 1.3±0.1 g/cm3 |
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| Molecular Formula | C24H27N5O2 |
| Molecular Weight | 417.504 |
| Exact Mass | 417.216461 |
| LogP | 3.83 |
| Index of Refraction | 1.675 |