1254032-66-0
1254032-66-0 structure
- Name: Besifovir
- Chemical Name: netarsudil
- CAS Number: 1254032-66-0
- Molecular Formula: C28H27N3O3
- Molecular Weight: 453.532
- Create Date: 2020-01-16 10:45:38
- Modify Date: 2024-01-11 16:51:12
-
Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2; 11 kinases are inhibited >90% in a panel of 422 kinases, only ROCK1 and ROCK2 (each 93% inhibition) and PKC (delta, 91%, and eta, 93% inhibition); exhibts improved bioavailability, demonstrates an effective and sustained IOP reduction for 24h after dosing; a novel ocular hypotensive agent for the treatment of glaucoma. Other Indication Approved
| Name | netarsudil |
|---|---|
| Synonyms |
Benzoic acid, 2,4-dimethyl-, [4-[(1S)-1-(aminomethyl)-2-(6-isoquinolinylamino)-2-oxoethyl]phenyl]methyl ester
netarsudil 4-[(2S)-3-Amino-1-(6-isoquinolinylamino)-1-oxo-2-propanyl]benzyl 2,4-dimethylbenzoate |
| Description | Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2; 11 kinases are inhibited >90% in a panel of 422 kinases, only ROCK1 and ROCK2 (each 93% inhibition) and PKC (delta, 91%, and eta, 93% inhibition); exhibts improved bioavailability, demonstrates an effective and sustained IOP reduction for 24h after dosing; a novel ocular hypotensive agent for the treatment of glaucoma. Other Indication Approved |
|---|---|
| References | References 1. Sturdivant JM, et al. Bioorg Med Chem Lett. 2016 May 15;26(10):2475-80. 2. Li G, et al. Eur J Pharmacol. 2016 Sep 15;787:20-31. 3. Lin CW, et al. J Ocul Pharmacol Ther. 2017 Jun 13. doi: 10.1089/jop.2017.0023. View Related Products by Target ROCK Other Indication |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 711.9±60.0 °C at 760 mmHg |
| Molecular Formula | C28H27N3O3 |
| Molecular Weight | 453.532 |
| Flash Point | 384.3±32.9 °C |
| Exact Mass | 453.205231 |
| LogP | 3.53 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.667 |