913612-38-1
913612-38-1 structure
- Name: Brexpiprazole dihydrochloride
- Chemical Name: Brexpiprazole dihydrochloride
- CAS Number: 913612-38-1
- Molecular Formula:
- Molecular Weight:
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2018-06-10 18:33:44
- Modify Date: 2024-01-03 11:58:28
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Brexpiprazole (OPC-34712) hydrochloride, an atypical orally active antipsychotic drug, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole hydrochloride is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole hydrochloride also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM)[1][2].
| Name | Brexpiprazole dihydrochloride |
|---|
| Description | Brexpiprazole (OPC-34712) hydrochloride, an atypical orally active antipsychotic drug, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole hydrochloride is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole hydrochloride also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM)[1][2]. |
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| Related Catalog | |
| Target |
5-HT1A Receptor:0.12 nM (Ki) 5-HT2A Receptor:0.47 nM (Ki) D2L Receptor:0.3 nM (Ki) human noradrenergic α1B:0.17 nM (Ki) human noradrenergic α2C:0.59 nM (Ki) |
| In Vitro | Brexpiprazole (0-1.0 μM, 4 days) potentiates NGF-induced neurite outgrowth in a dose-dependent manner in PC12 cells[1]. |
| In Vivo | Brexpiprazole (0-0.1 mg/kg; p.o.; once) improves social recognition deficits in mice[2]. Animal Model: Male C57BL/6NCrSlc mice, Dizocilpine (0.1 mg/kg) (HY-15084B) induced social recognition deficits[2] Dosage: 0.01, 0.03 and 0.1 mg/kg Administration: Oral administration, once Result: Significantly ameliorated Dizocilpine-induced social recognition deficits, without sedation or a reduction of exploratory behavior. |
| References |
| No Any Chemical & Physical Properties |