675599-62-9

675599-62-9 structure

Name: PG 01037 dihydrochloride
Chemical Name: N-{(2E)-4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]-2-buten-1-yl}-4-(2-pyridinyl)benzamide dihydrochloride
CAS Number: 675599-62-9
Molecular Formula: C₂₆H₂₈Cl₄N₄O
Molecular Weight: 554.339
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-06-16 00:13:29
Modify Date: 2024-01-11 10:46:33
PG01037 (dihydrochloride) is a potent and selective dopamine D3 receptor antagonist with a Ki of 0.7 nM[1].

Name	N-{(2E)-4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]-2-buten-1-yl}-4-(2-pyridinyl)benzamide dihydrochloride
Synonyms	Benzamide, N-[(2E)-4-[4-(2,3-dichlorophenyl)-1-piperazinyl]-2-buten-1-yl]-4-(2-pyridinyl)-, hydrochloride (1:2) N-{(2E)-4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]-2-buten-1-yl}-4-(2-pyridinyl)benzamide dihydrochloride

Description	PG01037 (dihydrochloride) is a potent and selective dopamine D3 receptor antagonist with a Ki of 0.7 nM[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D3 Receptor:0.7 nM (Ki)
References	[1]. Grundt P, et al. Novel heterocyclic trans olefin analogues of N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as selective probes with high affinity for the dopamine D3 receptor. J Med Chem. 2005 Feb 10;48(3):839-48.