1445700-01-5

1445700-01-5 structure

Name: TFMB-(R)-2-HG
Chemical Name: 3-(Trifluoromethyl)benzyl (2R)-5-oxotetrahydro-2-furancarboxylate
CAS Number: 1445700-01-5
Molecular Formula: C₁₃H₁₁F₃O₄
Molecular Weight: 288.219
Catalog: Research Areas Cancer
Create Date: 2018-06-14 02:37:05
Modify Date: 2024-01-02 21:48:43
TFMB-(R)-2-HG, a cell membrane-permeable version of (R)-2-HG, is a carcinogenic factor in Acute myeloid leukemia (AML).TFMB-(R)-2-HG impairs SCF ER-Hoxb8 cells differentiation in response to estrogen withdrawal[1].

Name	3-(Trifluoromethyl)benzyl (2R)-5-oxotetrahydro-2-furancarboxylate
Synonyms	3-(Trifluoromethyl)benzyl (2R)-5-oxotetrahydro-2-furancarboxylate 2-Furancarboxylic acid, tetrahydro-5-oxo-, [3-(trifluoromethyl)phenyl]methyl ester, (2R)-

Description	TFMB-(R)-2-HG, a cell membrane-permeable version of (R)-2-HG, is a carcinogenic factor in Acute myeloid leukemia (AML).TFMB-(R)-2-HG impairs SCF ER-Hoxb8 cells differentiation in response to estrogen withdrawal[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013 Mar 29;339(6127):1621-5.