11031-11-1

11031-11-1 structure

Name: Phleomycin D1
Chemical Name: O0VC1NEK5M
CAS Number: 11031-11-1
Molecular Formula: C₅₅H₈₆N₂₀O₂₁S₂
Molecular Weight: 1427.523
Catalog: Research Areas Infection
Create Date: 2018-07-12 20:09:21
Modify Date: 2024-01-03 11:53:50
Phleomycin D1 (PLM D1), a glycopeptide antibiotic, is a member of the Bleomycin/Phleomycin family. Phleomycin D1 causes cell death by binding and cleaving DNA[1][2][3].

Name	O0VC1NEK5M
Synonyms	(2R,3S,4S,5R,6R)-2-{[(2R,3S,4S,5S,6S)-2-[(1R,2S)-2-[({6-Amino-2-[(1S)-3-amino-1-{[(2S)-2,3-diamino-3-oxopropyl]amino}-3-oxopropyl]-5-methyl-4-pyrimidinyl}carbonyl)amino]-3-{[(2R,3S,4S)-5-({(2S,3R)-1-[(2-{(4'R)-4-[(4-carbamimidamidobutyl)carbamoyl]-4',5'-dihydro-2,4'-bi-1,3-thiazol-2'-yl}ethyl)amino]-3-hydroxy-1-oxo-2-butanyl}amino)-3-hydroxy-4-methyl-5-oxo-2-pentanyl]amino}-1-(1H-imidazol-4-yl)-3-oxopropoxy]-4,5-dihydroxy-6-(hydroxymethyl)t O0VC1NEK5M

Description	Phleomycin D1 (PLM D1), a glycopeptide antibiotic, is a member of the Bleomycin/Phleomycin family. Phleomycin D1 causes cell death by binding and cleaving DNA[1][2][3].
Related Catalog	Research Areas >> Infection
References	[1]. Oliva-Trastoy M, et, al. Resistance to the antibiotic Zeocin by stable expression of the Sh ble gene does not fully suppress Zeocin-induced DNA cleavage in human cells. Mutagenesis. 2005 Mar;20(2):111-4. [2]. Ishizuka M, et, al. Studies on antitumor activity, antimicrobial activity and toxicity of phleomycin. J Antibiot (Tokyo). 1966 Nov;19(6):260-71. [3]. Huang CH, et, al. Bifunctional intercalation of antitumor antibiotics BBM-928A and echinomycin with deoxyribonucleic acid. Effects of intercalation on deoxyribonucleic acid degradative activity of bleomycin and phleomycin. Biochemistry. 1982 Jul 20;21(15):3704-10.