226566-43-4

226566-43-4 structure

Name: RWJ-445167
Chemical Name: RWJ-445167
CAS Number: 226566-43-4
Molecular Formula: C₁₈H₂₄N₆O₅S
Molecular Weight: 436.485
Catalog: Signaling Pathways Metabolic Enzyme/Protease Factor Xa
Create Date: 2018-05-01 19:59:12
Modify Date: 2024-01-10 12:08:46
RWJ-445167 is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.

Name	RWJ-445167
Synonyms	N-[2-(Carbamimidamidooxy)ethyl]-2-[6-methyl-3-{[(3-methylphenyl)sulfonyl]amino}-2-oxo-1(2H)-pyridinyl]acetamide 1(2H)-Pyridineacetamide, N-[2-[[(aminoiminomethyl)amino]oxy]ethyl]-6-methyl-3-[[(3-methylphenyl)sulfonyl]amino]-2-oxo- N-[2-(carbamimidamidooxy)ethyl]-2-[6-methyl-3-{[(3-methylphenyl)sulfonyl]amino}-2-oxopyridin-1(2H)-yl]acetamide

Description	RWJ-445167 is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin Research Areas >> Cardiovascular Disease
Target	Ki: 4.0 nM (thrombin), 230 nM (factor Xa)[1]
References	[1]. RWJ-445167, et al. Exploration of potential prodrugs of RWJ-445167, an oxyguanidine-based dual inhibitor of thrombin and factor Xa. Chem Biol Drug Des. 2006 Jul;68(1):29-36.