DC Chemicals Limited
China
Product Name: A 71915
Price: ￥Inquiry/1g
Purity: 98.9%
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Contact: Tony Cao

132956-87-7

132956-87-7 structure

Name: (Arg6,β-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat) trifluoroacetate salt
Chemical Name: A 71915
CAS Number: 132956-87-7
Molecular Formula: C₆₉H₁₁₆N₂₆O₁₅S₂
Molecular Weight: 1613.974
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-02-21 02:16:32
Modify Date: 2024-01-04 11:13:17
A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells[1].

Name	A 71915
Synonyms	(Arg6,β-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat)

Description	A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
Target	A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist, with a pKi of 9.18.
In Vitro	A 71915 combines to Neuroblastoma NB-OK-1 cells, is used in the Cyclic GMP assay. A 71915 shifts the ANP dose-response curve of cyclic GMP production to the right[1].
In Vivo	A 71915 (5 μl; i.m.; 25-30 g male CD-1 mice) affects BNP (1 nmol)- and GRP (0.1 nmol)-induced scratching[2]. A 71915 (30 μg/ kg/ day) inhibits NS-398 on blood pressure decreased[3]. Animal Model: Rat (Male Sprague-Dawley); weighing 150-180 g[3] Dosage: 30 μg/kg/day; infused for 3 weeks Administration: via a mini-osmotic pump Result: The inhibitory effect of NS-398 on blood pressure was attenuated by the pretreatment with A 71915 (30 μg/kg/day).
References	[1]. Delporte C, et al. Discovery of a potent atrial natriuretic peptide antagonist for ANPA receptors in the human neuroblastoma NB-OK-1 cell line. Eur J Pharmacol. 1992;224(2-3):183-188. [2]. Kiguchi N, et al. Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice. [3]. Park BM, et al. Attenuation of renovascular hypertension by cyclooxygenase-2 inhibitor partly through ANP release. Peptides. 2015;69:1-8.

Density	1.5±0.1 g/cm3
Molecular Formula	C₆₉H₁₁₆N₂₆O₁₅S₂
Molecular Weight	1613.974
Exact Mass	1612.855
LogP	-5.73
Index of Refraction	1.698

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