Name | 4-N-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine |
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Synonyms |
8-<(4-amino-1-methylbutyl)amino>-2,6-dimethoxy-4-methyl-5-<3-(trifluoromethyl)phenoxy>quinoline
Tafenoquine N(4)-(2,6-Dimethoxy-4-methyl-5-((3-trifluoromethyl)phenoxy)-8-quinolinyl)-1,4-pentanediamine (R)-N3-(2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl)phenoxy)quinolin-8-yl)pentane-1,4-diamine 1,4-Pentanediamine,N4-(2,6-dimethoxy-4-methyl-5-(3-(trifluoromethyl)phenoxy)-8-quinolinyl) Tafenoquine (USAN) (RS)-N(sup 3)-(2,6-Dimethoxy-4-methyl-5-(3-trifluoro-methylphenoxy)quinolin-8-yl)pentane-1,4-diamine |
Description | Tafenoquine (WR 238605) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent[1]. |
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Related Catalog | |
Target |
Anti-malarial[1] |
In Vivo | Tafenoquine exhibits no anti-malarial activity in CYP 2D knock-out mice when dosed at their ED100 values (3 mg/kg) established in WT mice. Tafenoquine anti-malarial activity is partially restored in humanized/CYP 2D6 knock-in mice when tested at two times its ED100 (6 mg/kg)[1]. |
References |
Density | 1.237g/cm3 |
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Boiling Point | 565.6ºC at 760mmHg |
Molecular Formula | C24H28F3N3O3 |
Molecular Weight | 463.49300 |
Flash Point | 295.9ºC |
Exact Mass | 463.20800 |
PSA | 78.63000 |
LogP | 6.68410 |
Vapour Pressure | 8.17E-13mmHg at 25°C |
Index of Refraction | 1.572 |
Storage condition | 2-8℃ |