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106635-80-7

106635-80-7 structure
106635-80-7 structure
  • Name: Tafenoquine
  • Chemical Name: 4-N-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine
  • CAS Number: 106635-80-7
  • Molecular Formula: C24H28F3N3O3
  • Molecular Weight: 463.49300
  • Catalog: Signaling Pathways Anti-infection Parasite
  • Create Date: 2016-11-18 02:55:58
  • Modify Date: 2024-01-02 20:47:57
  • Tafenoquine (WR 238605) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent[1].

Name 4-N-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine
Synonyms 8-<(4-amino-1-methylbutyl)amino>-2,6-dimethoxy-4-methyl-5-<3-(trifluoromethyl)phenoxy>quinoline
Tafenoquine
N(4)-(2,6-Dimethoxy-4-methyl-5-((3-trifluoromethyl)phenoxy)-8-quinolinyl)-1,4-pentanediamine
(R)-N3-(2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl)phenoxy)quinolin-8-yl)pentane-1,4-diamine
1,4-Pentanediamine,N4-(2,6-dimethoxy-4-methyl-5-(3-(trifluoromethyl)phenoxy)-8-quinolinyl)
Tafenoquine (USAN)
(RS)-N(sup 3)-(2,6-Dimethoxy-4-methyl-5-(3-trifluoro-methylphenoxy)quinolin-8-yl)pentane-1,4-diamine
Description Tafenoquine (WR 238605) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent[1].
Related Catalog
Target

Anti-malarial[1]

In Vivo Tafenoquine exhibits no anti-malarial activity in CYP 2D knock-out mice when dosed at their ED100 values (3 mg/kg) established in WT mice. Tafenoquine anti-malarial activity is partially restored in humanized/CYP 2D6 knock-in mice when tested at two times its ED100 (6 mg/kg)[1].
References

[1]. Marcsisin SR, et al. Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds. Malar J. 2014 Jan 3;13:2.

Density 1.237g/cm3
Boiling Point 565.6ºC at 760mmHg
Molecular Formula C24H28F3N3O3
Molecular Weight 463.49300
Flash Point 295.9ºC
Exact Mass 463.20800
PSA 78.63000
LogP 6.68410
Vapour Pressure 8.17E-13mmHg at 25°C
Index of Refraction 1.572
Storage condition 2-8℃