98185-20-7

98185-20-7 structure

Name: Raclopride tartrate
Chemical Name: (S)-(-)-3,5-dichloro-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxysalicylamide L-(+)-tartrate
CAS Number: 98185-20-7
Molecular Formula: C₁₉H₂₆Cl₂N₂O₉
Molecular Weight: 497.32400
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-03-17 06:57:26
Modify Date: 2024-01-21 17:35:44
Raclopride tartrate is a selective dopamine D2/D3 receptor antagonist with potential antipsychotic effects. Raclopride tartrate binds to D2 and D3 receptors with Kis of 1.8 nM and 3.5 nM, respectively[1][2].

Name	(S)-(-)-3,5-dichloro-N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxysalicylamide L-(+)-tartrate
Synonyms	(S)-2-[(3,5-dichloro-6-methoxy-2-hydroxybenzamido)methyl]-1-ethylpyrrolidine L-tartrate raclopride tartarate raclopride tartrate (S)-2-[(3,5-dichloro-6-methoxy-2-hydroxybenzamido)methyl]-1-ethylpyrrolidine L-tartrate S(-)-RACLOPRIDE (+)-TARTRATE SALT

Description	Raclopride tartrate is a selective dopamine D2/D3 receptor antagonist with potential antipsychotic effects. Raclopride tartrate binds to D2 and D3 receptors with Kis of 1.8 nM and 3.5 nM, respectively[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D2 Receptor:1.8 nM (Ki) D3 Receptor:3.5 nM (Ki) D4 Receptor:2400 nM (Ki) D1 Receptor:18000 nM (Ki)
In Vivo	Raclopride tartrate (0.1, 0.3, or 0.6 mg/kg; IP; 30 min; albino male mice of the OF1 strain) significantly reduces time allocated to attack behavior[2].
References	[1]. Seeman P, et al. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994;15(7):264-270. [2]. Aguilar MA, et al. Behavioral profile of raclopride in agonistic encounters between male mice. Pharmacol Biochem Behav. 1994;47(3):753-756.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
RTECS	CV3465000