Name | Propynol Ethoxylate |
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Synonyms |
MFCD06411441
EINECS 223-601-1 2-(2-Propyn-1-yloxy)ethanol Propynol ethoxylate Ethanol, 2-(2-propyn-1-yloxy)- 2-(Prop-2-yn-1-yloxy)ethanol PME |
Description | Propynol Ethoxylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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Related Catalog | |
Target |
PEGs |
In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
References |
Density | 1.0±0.1 g/cm3 |
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Boiling Point | 168.7±15.0 °C at 760 mmHg |
Molecular Formula | C5H8O2 |
Molecular Weight | 100.116 |
Flash Point | 68.9±14.6 °C |
Exact Mass | 100.052429 |
PSA | 29.46000 |
LogP | -0.25 |
Vapour Pressure | 0.5±0.7 mmHg at 25°C |
Index of Refraction | 1.446 |
Storage condition | -20°C |
~60% 3973-18-0 |
Literature: Kislukhin, Alexander A.; Higginson, Cody J.; Hong, Vu P.; Finn Journal of the American Chemical Society, 2012 , vol. 134, # 14 p. 6491 - 6497 |
~% 3973-18-0 |
Literature: RIB-X PHARMACEUTICALS, INC. Patent: WO2004/29066 A2, 2004 ; Location in patent: Page/Page column 281 ; |
~67% 3973-18-0 |
Literature: Bovicelli; Mincione; Patamia Synthetic Communications, 1991 , vol. 21, # 7 p. 907 - 913 |
~% 3973-18-0 |
Literature: Hoffmann-La Roche Inc. Patent: US6130239 A1, 2000 ; US 6130239 A |
~% 3973-18-0 |
Literature: Erver, Florian; Kuttner, Julian R.; Hilt, Gerhard Journal of Organic Chemistry, 2012 , vol. 77, # 19 p. 8375 - 8385 |
~% 3973-18-0 |
Literature: Faure,R.; Descotes,G. Bulletin de la Societe Chimique de France, 1966 , p. 1569 - 1575 Full Text Show Details Bottini,A.T. et al. Journal of Organic Chemistry, 1965 , vol. 30, p. 2988 - 2994 |
~% 3973-18-0 |
Literature: Atavin,A.S. et al. Journal of Organic Chemistry USSR (English Translation), 1967 , vol. 3, p. 10 - 12 Zhurnal Organicheskoi Khimii, 1967 , vol. 3, # 1 p. 12 - 15 |
~% 3973-18-0 |
Literature: Pola,J. et al. Collection of Czechoslovak Chemical Communications, 1978 , vol. 43, p. 760 - 768 |
Precursor 10 | |
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DownStream 4 | |