745046-84-8
745046-84-8 structure
- Name: Ivachtin
- Chemical Name: 2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
- CAS Number: 745046-84-8
- Molecular Formula: C20H21N3O7S
- Molecular Weight: 447.462
- Catalog: Signaling Pathways Apoptosis Caspase
- Create Date: 2018-12-22 06:35:16
- Modify Date: 2024-01-10 13:10:53
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Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM. Ivachtin has modest selectivity for the remaining caspases[1].
| Name | 2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate |
|---|---|
| Synonyms |
2-[4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethyl acetate
1H-Pyrrolo[3,4-c]quinoline-1,3(2H)-dione, 2-[2-(acetyloxy)ethyl]-4-methyl-8-(4-morpholinylsulfonyl)- IVACHTIN Caspase-3 Inhibitor VII HMS3269H15 2-[4-Methyl-8-(4-morpholinylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethyl acetate |
| Description | Ivachtin (Caspase-3 Inhibitor VII; compound 7a) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor with an IC50 of 23 nM. Ivachtin has modest selectivity for the remaining caspases[1]. |
|---|---|
| Related Catalog | |
| Target |
Caspase-3:23 nM (IC50) |
| In Vitro | Ivachtin (Caspase-3 Inhibitor VII; compound 7a; 10, 100 μM) has protective effect in a model of staurosporininduced apoptosis in human Jurkat T cells[1]. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 665.0±65.0 °C at 760 mmHg |
| Molecular Formula | C20H21N3O7S |
| Molecular Weight | 447.462 |
| Flash Point | 356.0±34.3 °C |
| Exact Mass | 447.110016 |
| PSA | 131.56000 |
| LogP | 1.30 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.632 |
| Precursor 4 | |
|---|---|
| DownStream 0 | |