92169-45-4
92169-45-4 structure
- Name: Neuromedin N trifluoroacetate salt
- Chemical Name: 2-[[2-[[2-[[1-[2-(2,6-diaminohexanoylamino)-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
- CAS Number: 92169-45-4
- Molecular Formula: C38H63N7O8
- Molecular Weight: 745.94900
- Catalog: Peptides
- Create Date: 2018-12-10 12:28:56
- Modify Date: 2024-01-02 18:53:28
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Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Sequence: Lys-Ile-Pro-Tyr-Ile-Leu.
| Name | 2-[[2-[[2-[[1-[2-(2,6-diaminohexanoylamino)-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid |
|---|---|
| Synonyms |
neuromedin N
Lys-ile-pro-tyr-ile-leu |
| Description | Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Sequence: Lys-Ile-Pro-Tyr-Ile-Leu. |
|---|---|
| Related Catalog | |
| Target |
Dopamine D2 receptor[1]. |
| In Vitro | Neuromedin N competitively inhibits the binding of neurotensin to rat brain synaptic membranes with a 19-fold lower potency than neurotensin and is rapidly inactivated by brain synaptic peptidases[1]. It competitively inhibits neurotensin binding to rat brain synaptic membranes and has increased potency in the presence of the peptidase inhibitor bestatin[2]. |
| References |
| Molecular Formula | C38H63N7O8 |
|---|---|
| Molecular Weight | 745.94900 |
| Exact Mass | 745.47400 |
| PSA | 246.28000 |
| LogP | 4.44620 |
| Storage condition | -20°C |
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Detail
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| Literature: Kiso; Kimura; Fujiwara; Sakikawa; Akaji Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 1 p. 270 - 272 |
| Precursor 3 | |
|---|---|
| DownStream 0 | |