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491-54-3

491-54-3 structure

Name: Kaempferide
Chemical Name: kaempferide
CAS Number: 491-54-3
Molecular Formula: C₁₆H₁₂O₆
Molecular Weight: 300.263
Catalog: Natural product Flavonoids
Create Date: 2018-05-09 08:00:00
Modify Date: 2024-01-02 11:47:15
Kaempferide is an O-methylated flavonol, a type of chemical compound. It can be found in Kaempferia galanga (aromatic ginger). The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L-methionine and kaempferol to produce S-adenosyl-L-homocysteine and kaempferide. P-glycoproteins.

Name	kaempferide
Synonyms	4'-O-Methylkaempferol Kaempferol 4'-methyl ether 3,5,7-trihydroxy-2-(4-methoxyphenyl)chromen-4-one 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one 3,5,7-trihydroxy-4'-methoxyflavone Kaempferid Kaempferide 3 5 7-trihydroxy-4'-methoxyflavone 4'-Methoxy-3,5,7-trihydroxyflavone 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-methoxyphenyl)- 3,5,7-trihydroxy-4′-methoxyflavone 4'-Methylkaempferol

Description	Kaempferide is an O-methylated flavonol, a type of chemical compound. It can be found in Kaempferia galanga (aromatic ginger). The enzyme kaempferol 4'-O-methyltransferase uses S-adenosyl-L-methionine and kaempferol to produce S-adenosyl-L-homocysteine and kaempferide. P-glycoproteins.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Others >> Estrogen Receptor/ERR Natural Products >> Flavonoids Research Areas >> Others
References	[1]. Otake Y, Walle T. Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9. Drug Metab Dispos. 2002 Feb;30(2):103-5. [2]. Martineti V, Tognarini I, Azzari C et al. Inhibition of in vitro growth and arrest in the G0/G1 phase of HCT8 line human colon cancer cells by kaempferide triglycoside from Dianthus caryophyllus. Phytother Res. 2010 Sep;24(9):1302-8. [3]. Pahua-Ramos, Maria Elena; Ortiz-Moreno, Alicia; Chamorro-Cevallos, German et al. Hypolipidemic Effect of Avocado (Persea americana Mill) Seed in a Hypercholesterolemic Mouse Model. Plant Foods for Human Nutrition (New York, NY, United States) (2012), 67(1), 10-16. [4]. Soucek, Pavel; Kondrova, Eliska; Hermanek, Josef et al. New model system for testing effects of flavonoids on doxorubicin-related formation of hydroxyl radicals. Anti-Cancer Drugs (2011), 22(2), 176-184.

Density	1.5±0.1 g/cm3
Boiling Point	543.8±50.0 °C at 760 mmHg
Melting Point	156-157ºC(lit.)
Molecular Formula	C₁₆H₁₂O₆
Molecular Weight	300.263
Flash Point	207.1±23.6 °C
Exact Mass	300.063385
PSA	100.13000
LogP	2.74
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.710
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK6915000

CHEMICAL NAME :: Flavanone, 4'-methoxy-3,5,7-trihydroxy-

CAS REGISTRY NUMBER :: 491-54-3

BEILSTEIN REFERENCE NO. :: 0305378

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H12-O6

MOLECULAR WEIGHT :: 300.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: BCSTB5 Biochemical Society Transactions. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1973- Volume(issue)/page/year: 5,1489,1977

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	KD4170000
HS Code	29329990

3570-69-2

~56%

491-54-3

Literature: Pandurangan; Bose, Chinchu; Banerji Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5328 - 5330

1258963-38-0

3615-41-6

491-54-3

Literature: Lu, Juan; Jin, Yongri; Liu, Guiying; Zhu, Na; Gui, Mingyu; Yu, Aimin; Li, Xuwen Chemistry of Natural Compounds, 2010 , vol. 46, # 2 p. 205 - 208

689260-84-2

491-54-3

Literature: Pandurangan; Bose, Chinchu; Banerji Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5328 - 5330

36804-11-2

491-54-3

Literature: Pandurangan; Bose, Chinchu; Banerji Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5328 - 5330

123-11-5

491-54-3

Literature: Pandurangan; Bose, Chinchu; Banerji Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5328 - 5330

65982-77-6

794-94-5

491-54-3

Literature: Heap; Robinson Journal of the Chemical Society, 1926 , p. 2339

520-18-3

1592-70-7

491-54-3

Literature: Brunet, Gunter; Ibrahim, Ragai K. Phytochemistry (Elsevier), 1980 , vol. 19, p. 741 - 746

20869-95-8

491-54-3

Literature: Rao; Seshadri Journal of the Chemical Society, 1947 , p. 122

108-73-6

491-54-3

Literature: Heap; Robinson Journal of the Chemical Society, 1926 , p. 2339

Precursor 9
3570-69-2 689260-84-2 36804-11-2 123-11-5
65982-77-6 794-94-5 520-18-3 20869-95-8
108-73-6
DownStream 5
100-09-4 144-62-7 64-18-6 108-73-6
38681-32-2

491-54-3	17353-03-6
38681-32-2	16290-08-7
1010795-61-5