DC Chemicals Limited
China
Product Name: NS-102
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

136623-01-3

136623-01-3 structure

136623-01-3 structure

Name: NS-102
Chemical Name: 3-(hydroxyamino)-5-nitro-6,7,8,9-tetrahydrobenzo[g]indol-2-one
CAS Number: 136623-01-3
Molecular Formula: C₁₂H₁₁N₃O₄
Molecular Weight: 261.23300
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-11-24 22:47:24
Modify Date: 2024-01-10 14:21:51
NS-102 is a selective kainate (GluK2) receptors antagonist. NS-102 is a potent GluR6/7 receptor antagonist[1][2][3].

Name	3-(hydroxyamino)-5-nitro-6,7,8,9-tetrahydrobenzo[g]indol-2-one
Synonyms	1H-Benz[g]indole-2,3-dione,6,7,8,9-tetrahydro-5-nitro-,3-oxime NS 102 6,7,8,9-Tetrahydro-5-nitro-1H-benz[g]indole-2,3-dione 3-oxime

Description	NS-102 is a selective kainate (GluK2) receptors antagonist. NS-102 is a potent GluR6/7 receptor antagonist[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	Combination of NS-102 (10 μM) and GYKI 52466 (30 μM) preventes full loss of compound action potentials (CAPs) during oxygen and glucose deprivation (OGD) and increased CAP area recovery[1].
In Vivo	NS-102 (20, 40 or 80 μmol/litre ; in the hippocampal CA3 region) significantly reduces Sevoflurane-induced hyperactivities[1].
References	[1]. Selva Baltan Tekkök, et al. Excitotoxic mechanisms of ischemic injury in myelinated white matter. J Cereb Blood Flow Metab. 2007 Sep;27(9):1540-52. [2]. P Liang, et al. Sevoflurane activates hippocampal CA3 kainate receptors (Gluk2) to induce hyperactivity during induction and recovery in a mouse model. Br J Anaesth. 2017 Nov 1;119(5):1047-1054. [3]. Barbara Gisabella, et al. Kainate receptor-mediated modulation of hippocampal fast spiking interneurons in a rat model of schizophrenia. PLoS One. 2012;7(3):e32483.

Density	1.74g/cm3
Boiling Point	405.8ºC at 760mmHg
Molecular Formula	C₁₂H₁₁N₃O₄
Molecular Weight	261.23300
Flash Point	199.2ºC
Exact Mass	261.07500
PSA	107.51000
LogP	2.13230
Vapour Pressure	2.81E-08mmHg at 25°C
Index of Refraction	1.794

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