352431-50-6

352431-50-6 structure

Name: 17β-Estradiol sulfate-d4 sodium
Chemical Name: sodium 17beta-estradiol-2,4,16,16-d4 3-sulfate
CAS Number: 352431-50-6
Molecular Formula: C₁₈H₁₉D₄NaO₅S
Molecular Weight: 378.45
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2018-03-23 08:00:00
Modify Date: 2024-01-09 16:27:47
17β-Estradiol sulfate-d4 (sodium) is the deuterium labeled 17β-Estradiol sulfate 17β-Estradiol sulfate (sodium), also known as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid[1][2].

Name	sodium 17beta-estradiol-2,4,16,16-d4 3-sulfate
Synonyms	Estra-1,3,5(10)-triene-2,4,16,16-d-3,17-diol, 3-(hydrogen sulfate), sodium salt, (17β)- (1:1) Sodium (17β)-17-hydroxy(2,4,16,16-H)estra-1,3,5(10)-trien-3-yl sulfate

Description	17β-Estradiol sulfate-d4 (sodium) is the deuterium labeled 17β-Estradiol sulfate 17β-Estradiol sulfate (sodium), also known as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Li W, et al. Neuroactive steroids and human recombinant rho1 GABAC receptors. J Pharmacol Exp Ther. 2007;323(1):236-247. [3]. Schneider C, et al. A novel enzyme-linked immunosorbent assay for ethynylestradiol using a long-chain biotinylated EE2 derivative. Steroids. 2004;69(4):245-253.