DC Chemicals Limited
China
Product Name: Methylmethionine sulfonium chloride
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Vitamin U
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Purity: 98.0%
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Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: (3-amino-3-carboxypropyl)dimethyl-,chloride,l-sulfoniu
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

1115-84-0

1115-84-0 structure

Name: dl-methionine methylsulfonium chloride
Chemical Name: L-Methionine-S-methyl Sulfonium Chloride
CAS Number: 1115-84-0
Molecular Formula: C₆H₁₄ClNO₂S
Molecular Weight: 199.69900
Catalog: Organic raw materials Inorganic acid ester
Create Date: 2018-04-26 08:00:00
Modify Date: 2024-01-04 14:02:53
Vitamin U (S-Methylmethionine sulfonium) chloride is an orally active anti-ulcer agent with antioxidant activity. Vitamin U inhibits adipocyte differentiation. Vitamin U promotes skin wound healing.Vitamin U can be used in the research of gastrointestinal ulceration[1][2][3][4][5].

Name	L-Methionine-S-methyl Sulfonium Chloride
Synonyms	dl-methionine methylsulfonium chloride d,l-(3-amino-3-carboxypropyl)dimethyl sulfonium chloride l-methionine s-methylsulfonium chloride methylmethioninesulfonium chloride dl-(3-amino-3-carboxypropyl) dimethylsulfonium chloride EINECS 200-625-0 dl-methylmethioninesulfonium chloride methiosulfonium chloride MFCD00031700 methylmethionine sulfonium chloride

Description	Vitamin U (S-Methylmethionine sulfonium) chloride is an orally active anti-ulcer agent with antioxidant activity. Vitamin U inhibits adipocyte differentiation. Vitamin U promotes skin wound healing.Vitamin U can be used in the research of gastrointestinal ulceration[1][2][3][4][5].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Vitamin U chloride (100 μM, 24 h) promotes the growth and migration of human dermal fibroblasts(hDFs)[1]. Vitamin U chloride (0-1 mM, 24 h) activates ERK1/2 in hDFs[1]. Vitamin U chloride (0.1 g/L in the nutrient solution) reduces cell membrane damage in higher plants exposed to low-temperature stress[2]. Vitamin U chloride (10-100 mM, 7 days) inhibits adipocyte differentiation via down-regulation of adipogenic factors and up-regulation of AMPK activity[3]. Cell Proliferation Assay[1] Cell Line: Human dermal fibroblasts(hDFs) Concentration: 100 μM Incubation Time: 24 h Result: Promoted hDFs proliferation. Western Blot Analysis[3] Cell Line: 3T3-L1 cells Concentration: 50, 70, 90 mM Incubation Time: 7 days Result: Increased AMPK phosphorylation and decreased PPAR-γ levels.
In Vivo	Vitamin U chloride (50 mg/kg, oral gavage) prevents valproic acid-induced liver injury in rats[4]. Vitamin U chloride (50 mg/kg, oral gavage for 3 days) shows antioxidant effect and prevents GalN-induced gastric damage in rats[5]. Animal Model: Valproic acid (VPA)-induced rats with liver damage[4] Dosage: 50 mg/kg Administration: Oral gavage Result: Blocked the decrease in catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activities. Increased in the levels of IL-1β, active caspase-3, and cytoplasmic cytochrome c. Increased in the number of proliferating cells nuclear antigen (PCNA) positive hepatocytes.
References	[1]. Won-Serk Kim, et al. Accelerated wound healing by S-methylmethionine sulfonium: evidence of dermal fibroblast activation via the ERK1/2 pathway. Pharmacology. 2010;85(2):68-76. [2]. Ilona Rácz, et al. S-methylmethionine reduces cell membrane damage in higher plants exposed to low-temperature stress. J Plant Physiol. 2008 Sep 29;165(14):1483-90. [3]. Na Young Lee, et al. Inhibitory Effect of Vitamin U (S-Methylmethionine Sulfonium Chloride) on Differentiation in 3T3-L1 Pre-adipocyte Cell Lines. Ann Dermatol. 2012 Feb;24(1):39-44. [4]. Ertan Celik, et al. Vitamin U prevents valproic acid-induced liver injury through supporting enzymatic antioxidant system and increasing hepatocyte proliferation triggered by inflammation and apoptosis. Toxicol Mech Methods. 2021 Oct;31(8):600-608. [5]. Dileknur Topaloglu, et al. Gastroprotective effect of vitamin U in D-galactosamine-induced hepatotoxicity. J Biochem Mol Toxicol. 2022 Sep;36(9):e23124.

Melting Point	134ºC
Molecular Formula	C₆H₁₄ClNO₂S
Molecular Weight	199.69900
Exact Mass	199.04300
PSA	88.62000
LogP	1.16860

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WR7440000

CHEMICAL NAME :: Sulfonium, (3-amino-3-carboxypropyl)dimethyl-, chloride, L-

CAS REGISTRY NUMBER :: 1115-84-0

LAST UPDATED :: 199103

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H14-N-O2-S.Cl

MOLECULAR WEIGHT :: 199.72

WISWESSER LINE NOTATION :: QVYZ2S1&1 &G &6/12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,835,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,835,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 432 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,835,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,835,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,835,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 259 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,835,1982

Hazard Codes	Xn,N,T,F
Risk Phrases	R10:Flammable. R20:Harmful by inhalation. R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . R40:Limited evidence of a carcinogenic effect. R39/23/24/25:Toxic: danger of very serious irreversible effects thr
Safety Phrases	S24/25-S61-S36/37-S45
RIDADR	UN 1134 3/PG 3
WGK Germany	2
RTECS	CZ0175000
Packaging Group	III
Hazard Class	3
HS Code	2930909090

63-68-3

74-88-4

~72%

1115-84-0

Literature: Mladkova, Jana; Vanek, Vaclav; Budesinsky, Milos; Elbert, Tomas; Demianova, Zuzana; Garrow, Timothy A.; Jiracek, Jiri Journal of Medicinal Chemistry, 2012 , vol. 55, # 15 p. 6822 - 6831

Precursor 2
63-68-3 74-88-4
DownStream 2
75-18-3 672-15-1

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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