53995-62-3

53995-62-3 structure

Name: PFI-90
Chemical Name: N'-(pyridin-2-yl)picolinohydrazide
CAS Number: 53995-62-3
Molecular Formula: C₁₁H₁₀N₄O
Molecular Weight: 214.22300
Catalog: Signaling Pathways Epigenetics Histone Demethylase
Create Date: 2017-04-27 12:28:21
Modify Date: 2024-01-11 10:56:05
PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).

Name	N'-(pyridin-2-yl)picolinohydrazide
Synonyms	MFCD27925103

Description	PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Demethylase
Target	IC50: 812 nM (RH4); 3200 nM (RH30); 1895 nM (OSA-CL); 1113 nM (TC-32)[1]
In Vitro	PFI-90 shows dose response in RH4, RH30, OSA-CL and TC-32 cells, with IC50s of 812, 3200, 1895 and 1113 nM, respectively[1]. PFI-90 (3 μΜ; 24 hours) increases apoptosis in RH4 and SCMC cells[1]. Western Blot Analysis[1] Cell Line: RH4 and SCMC cells Concentration: 3 μΜ Incubation Time: 24 hours Result: Apoptosis increased in RH4 and SCMC cells.
References	[1]. KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1.

Hazard Codes	Xi

Precursor 0
DownStream 1
5006-54-2