Name | 2-phenyl-4-(2-piperidin-4-ylethyl)quinoline |
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Synonyms |
Pipequalina
Pipequalina [Spanish] Pipequalinum [Latin] Quinoline,2-phenyl-4-(2-(4-piperidinyl)ethyl) 2-Phenyl-4-(2-(4-piperidyl)ethyl)quinoline 2-phenyl-4-[2-(piperidin-4-yl)ethyl]quinoline Pipequalinum PK-8165 Pipequaline |
Description | Pipequaline (PK 8165) is a non-selective GABAA receptor partial agonist with anxiolytic activity. |
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Related Catalog | |
In Vitro | Pipequaline is extensively bound to plasma proteins: i.e. human serum albumin (HSA), alpha-1-acid glycoprotein (AAG), lipoproteins and blood cells, mainly erythrocytes[1]. |
In Vivo | Intravenously administered pipequaline exerts a partial suppression of activations by kainate, glutamate and acetylcholine. Microiontophoretic applications of pipequaline reduces the neuronal activation by kainate[2]. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made[3]. |
Animal Admin | Rats: Pipequaline is dissolved in water to give injection volumes of 2 mL/kg. Rats are injected with 5, 10, and 50 mg/kg pipequaline. Infrared cells in the walls of the box provided automated measures of locomotor activity and rearing, respectively[3]. |
References |
Density | 1.078g/cm3 |
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Boiling Point | 489.2ºC at 760 mmHg |
Molecular Formula | C22H24N2 |
Molecular Weight | 316.43900 |
Flash Point | 249.7ºC |
Exact Mass | 316.19400 |
PSA | 24.92000 |
LogP | 5.16280 |
Index of Refraction | 1.602 |
Storage condition | 2-8℃ |