- DC Chemicals Limited
- China
- Product Name: Z-LLNle-CHO
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Taiwan Oyi peptide Co. Ltd
- China
- Product Name: Z-Leu-Leu-Nle-aldehyde
- Price: $Inquiry/1mg $Inquiry/100kg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Vinnie
133407-83-7
133407-83-7 structure
- Name: Z-Leu-Leu-Nle-aldehyde
- Chemical Name: benzyl N-[4-methyl-1-[[4-methyl-1-oxo-1-(1-oxohexan-2-ylamino)pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
- CAS Number: 133407-83-7
- Molecular Formula: C26H41N3O5
- Molecular Weight: 475.62100
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-12-26 18:44:49
- Modify Date: 2024-01-07 19:17:43
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Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia[1][2].
| Name | benzyl N-[4-methyl-1-[[4-methyl-1-oxo-1-(1-oxohexan-2-ylamino)pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate |
|---|---|
| Synonyms |
Z-Leu-Leu-Nle-H
benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxohexan-2-yl]amino]pentan-2-yl]amino]-1-oxopentan-2-yl]carbamate IN1097 Z*Leu-Leu-Nle-CHO Z-Leu-Leu-Nle-aldehyde |
| Description | Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia[1][2]. |
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| Related Catalog | |
| In Vitro | Z-LLNle-CHO (0-5 µM or 0-3 µM; 72 h) results in a dose-dependent decrease in cell viability/proliferation in six breast cancer cell lines[1]. Z-LLNle-CHO shows proteasome inhibitory activity, which contributes to cytotoxicity to MCF-7 cells[1]. Z-LLNle-CHO blocks Akt-mediated pro-survival pathways and induces caspase- and ROS-dependent cell apoptosis in Nalm6 and 697 cells[2]. Cell Viability Assay[1] Cell Line: MCF-7, BT474, T47D, MDA-MB-231, SKBR3, and MDA-MB-468 cells Concentration: 0-5 µM (for MCF-7); 0-3 µM Incubation Time: 72 h Result: Inhibited MCF-7, BT474, T47D, MDA-MB-231, SKBR3, and MDA-MB-468 cells with ED50 values of 3.25, 2.5, 2.4, 1.8, 1.6, and 1.4 μM, respectively. Apoptosis Analysis[2] Cell Line: Precursor-B ALL cells Concentration: 0-2.5 µM Incubation Time: 18-24 h Result: Induced cell apoptosis. |
| In Vivo | Z-LLNle-CHO (5 mg/kg; s.c.; single daily for 12 days) inhibits engraftment of B-lymphoblasts in precursor-B ALL xenograft model[2]. Animal Model: Female SCID/NOD mice (6-8-week-old; precursor-B ALL xenograft model)[2]. Dosage: 5 mg/kg Administration: Subcutaneous injection; single daily for 12 days Result: Delayed or prevented engraftment of B-lymphoblasts in 50% of the animals comprising the experimental group. |
| Molecular Formula | C26H41N3O5 |
|---|---|
| Molecular Weight | 475.62100 |
| Exact Mass | 475.30500 |
| PSA | 113.60000 |
| LogP | 4.90500 |
| WGK Germany | 3 |
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