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Related CAS#:
113-24-6 220803-31-6
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113-24-6

113-24-6 structure
113-24-6 structure
  • Name: Sodium 2-oxopropanoate
  • Chemical Name: sodium pyruvate
  • CAS Number: 113-24-6
  • Molecular Formula: C3H3NaO3
  • Molecular Weight: 110.04
  • Catalog: Organic raw materials Organometallic salt
  • Create Date: 2018-02-04 08:00:00
  • Modify Date: 2024-01-02 10:08:58
  • Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[1][2].
Name sodium pyruvate
Synonyms PYRUVATE
PYR NA
Pyruvic acid,sodium salt
sodium 2-oxopropanoate
Sodium pyroracemate
p.A.,100g
Sodium pyruate
SodiuM Pyruvate
Pyruvic acid sodium salt
pyruvic acid sodium
2-oxopropanoic acid sodium salt
sodium salt of pyruvic acid
EINECS 204-024-4
SodiuM pyrovaceMate
BioChemica,100g
MFCD00002586
Description Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS[1][2].
Related Catalog
Target

Microbial Metabolite
In Vitro In the process of scavenging hydrogen peroxide, Sodium 2-oxopropanoate (Sodium pyruvate) is decarboxylated to lactate and hence diverted away from aerobic metabolism and further ROS generation. Under conditions in which pyruvate stimulated JNK1 activity, both mitochondrial and cytosolic ROS levels rose. An increase in JNK1 activity in a variety of different cell types over a range of pyruvate concentrations are observed[1]. Sodium 2-oxopropanoate (Sodium pyruvate) is an effective scavenger of H2O2 as well as of O2▪-, thereby protecting the lens against oxidative stress and consequent cataract formation, under in vitro as well as in vivo conditions, Sodium 2-oxopropanoate has also been shown to protect the lens proteins against glycation by competitively inhibiting the initial reaction between the sugar carbonyl and the protein -NH2[2].
In Vivo Neonatal rats are given a bolus of Sodium 2-oxopropanoate (Sodium pyruvate; 0.1-10 g/kg), and 1 h later, levels of JNK1 activity were determined in liver extracts. Sodium 2-oxopropanoate (Sodium pyruvate) addition resulted in a significant increase in JNK1 activity. Analysis of serum levels of Sodium 2-oxopropanoate in neonatal rats revealed that baseline levels of pyruvate are 0.30 mM. At the time of sacrifice, following the largest dose of Sodium 2-oxopropanoate, serum levels rose approximately sixfold to 1.84 mM[1].
References

[1]. S Nemoto, et al. Role for mitochondrial oxidants as regulators of cellular metabolism. Mol Cell Biol. 2000 Oct;20(19):7311-8.

[2]. W Zhao, et al. Fructose induced deactivation of antioxidant enzymes: preventive effect of pyruvate. Free Radic Res. 2000 Jul;33(1):23-30.
Density 1.267g/cm3
Boiling Point 165ºC at 760 mmHg
Melting Point >300 °C(lit.)
Molecular Formula C3H3NaO3
Molecular Weight 110.04
Flash Point 54.3ºC
Exact Mass 109.997986
PSA 57.20000
Vapour Pressure 0.968mmHg at 25°C
Index of Refraction 1.426-1.43
Storage condition 2-8°C
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility H2O: 100 mg/mL
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S37/39-S26-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 29183000
79-41-4 structure

79-41-4

~93%

113-24-6 structure

113-24-6
Literature: GE HEALTHCARE AS Patent: WO2008/48106 A1, 2008 ; Location in patent: Page/Page column 18 ;
127-17-3 structure

127-17-3

~94%

113-24-6 structure

113-24-6
Literature: SKW Trostberg Aktiengesellschaft Patent: US6232497 B1, 2001 ;
920-49-0 structure

920-49-0

~%

113-24-6 structure

113-24-6
Literature: Process Biochemistry, , vol. 48, # 1 p. 109 - 117
21593-77-1 structure

21593-77-1

~%

2179-57-9 structure

2179-57-9
539-86-6 structure

539-86-6
29418-05-1 structure

29418-05-1
Detail
Literature: Journal of Organic Chemistry, , vol. 59, # 11 p. 3227 - 3229
1138160-36-7 structure

1138160-36-7

~%

113-24-6 structure

113-24-6

100-52-7 structure

100-52-7
Literature: Angewandte Chemie - International Edition, , vol. 48, # 5 p. 922 - 925
56-41-7 structure

56-41-7
114-76-1 structure

114-76-1

~%

150-30-1 structure

150-30-1
113-24-6 structure

113-24-6
Literature: Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 1919 - 1924
5824-58-8 structure

5824-58-8

~%

113-24-6 structure

113-24-6
Literature: Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , # 2 p. 263 - 267
312-85-6 structure

312-85-6

~%

113-24-6 structure

113-24-6
Literature: Bulletin de la Societe Chimique de France, , vol. 132, # 10 p. 1039 - 1046
HS Code 2918300090
Summary 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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title: CAS No. 113-24-6 | Chemsrc address: https://www.chemsrc.com/en/baike/1094491.html

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