Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: SIA Crosslinker
Price: ￥648.0/25mg ￥1818.0/100mg
Purity: 95.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: SIA Crosslinker
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-SUCCINIMIDYL IODOACETATE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

39028-27-8

39028-27-8 structure

39028-27-8 structure

Name: SIA Crosslinker
Chemical Name: iodoacetic acid n-hydroxysuccinimide ester
CAS Number: 39028-27-8
Molecular Formula: C₆H₆INO₄
Molecular Weight: 283.021
Catalog: Chemical reagent Organic reagent Imide
Create Date: 2018-03-03 08:00:00
Modify Date: 2024-01-02 18:11:47
SIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name	iodoacetic acid n-hydroxysuccinimide ester
Synonyms	1-(2-Iodoacetoxy)-2,5-pyrrolidinedione N-SucciniMidyl Iodoacetate 2,5-Pyrrolidinedione, 1-[(2-iodoacetyl)oxy]- N-(Iodoacetoxy)succinimide 1-(2-Iodoacetoxy)pyrrolidine-2,5-dione Iodoacetic Acid N-Succinimidyl Ester (2,5-dioxopyrrolidin-1-yl) 2-iodoacetate N-Succinimidyl iodoacetate(SIA)

Description	SIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Density	2.1±0.1 g/cm3
Boiling Point	315.6±44.0 °C at 760 mmHg
Melting Point	148ºC
Molecular Formula	C₆H₆INO₄
Molecular Weight	283.021
Flash Point	144.7±28.4 °C
Exact Mass	282.934143
PSA	63.68000
LogP	-0.76
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.615
Storage condition	−20°C
Water Solubility	DMF: 50 mg/mL

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2925190090

6066-82-6 structure

6066-82-6

64-69-7 structure

64-69-7

~29%

39028-27-8 structure

39028-27-8

Literature: Marco Colas, Maria Pilar; Sánchez Baeza, Francisco José; González Pinacho, Daniel Patent: US2013/273581 A1, 2013 ; Location in patent: Page/Page column 0092; 0111-0112; 0114 ;

Precursor 2
6066-82-6 64-69-7
DownStream 0

HS Code	2925190090
Summary	2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%