183320-51-6

183320-51-6 structure

Name: OSI-420
Chemical Name: 2-[4-(3-ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxyethanol,hydrochloride
CAS Number: 183320-51-6
Molecular Formula: C₂₁H₂₂ClN₃O₄
Molecular Weight: 415.870
Catalog: Biochemical Inhibitor Protein tyrosine kinase
Create Date: 2018-07-14 22:06:25
Modify Date: 2024-01-02 17:58:40
Desmethyl Erlotinib (OSI-420) is an active metabolite of erlotinib, which is a potent EGFR tyrosin kinase inhibitor.

Name	2-[4-(3-ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxyethanol,hydrochloride
Synonyms	OSI-420 2-({4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl}oxy)ethanol hydrochloride (1:1) Desmethyl erlotinib hydrochloride Ethanol, 2-[[4-[(3-ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]-, hydrochloride (1:1) S2205_Selleck Desmethyl Erlotinib Erlotinib Impurity 4

Description	Desmethyl Erlotinib (OSI-420) is an active metabolite of erlotinib, which is a potent EGFR tyrosin kinase inhibitor.
Related Catalog	Research Areas >> Cancer
In Vivo	Desmethyl Erlotinib exposure (AUC) in plasma is 30% (range 12-59%) of erlotinib, and Desmethyl Erlotinib clearance is more than 5-fold higher than erlotinib. The CSF penetration of erlotinib and Desmethyl Erlotinib is <5% relative to total plasma concentration[1].
References	[1]. Meany HJ, et al. The plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite (OSI-420) after intravenous administration of erlotinib in non-human primates. Cancer Chemother Pharmacol. 2008, 62(3), 387-392.