565-20-8

565-20-8 structure

Name: N-acetyl Dapsone
Chemical Name: N-Acetyl Dapsone
CAS Number: 565-20-8
Molecular Formula: C₁₄H₁₄N₂O₃S
Molecular Weight: 290.34
Catalog: Chemical reagent Organic reagent Sulfone, sulfoxide compound
Create Date: 2018-03-19 08:00:00
Modify Date: 2024-01-02 20:17:50
N-Acetyl dapsone (MADDS) is the major metabolite of Dapsone (HY-B0688). Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1][2].

Name	N-Acetyl Dapsone
Synonyms	N-[4-(4-aminophenyl)sulfonylphenyl]acetamide Mono-N-acetyl-4-4'-sulfonylbisbenzeneamine

Description	N-Acetyl dapsone (MADDS) is the major metabolite of Dapsone (HY-B0688). Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Tanaka K, et al. Mutagenicity of N-acetyl and N,N'-diacetyl derivatives of 3 aromatic amines used as epoxy-resin hardeners. Mutat Res. 1985 May-Jun;143(1-2):11-5. [2]. Bonde S L, et al. Simultaneous determination of dapsone and its major metabolite N-Acetyl Dapsone by LC-MS/MS method. Int. J. Pharm. Pharm. Sci, 2013, 5: 441-446.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 6,251,1951