Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Triprolidine
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Purity: 98.0%
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486-12-4

486-12-4 structure

486-12-4 structure

Name: triprolidine
Chemical Name: triprolidine
CAS Number: 486-12-4
Molecular Formula: C₁₉H₂₂N₂
Molecular Weight: 278.39100
Catalog: API Antiallergic Antihistamine
Create Date: 2018-06-23 12:24:41
Modify Date: 2024-01-05 09:28:26
Triprolidine is an orally active H1R Antagonist antagonist. Triprolidine has the function of spinal cord motor and sensory block. Triprolidine can be used for the research of allergic rhinitis[1][2][3].

Name	triprolidine
Synonyms	MFCD00038040 (e)-pyridin Triprolidin (E)-2-[3-(1-Pyrrolidinyl)-1-p-toluenepropenyl]pyridine (E)-1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidino prop-1-ene trans-2-[3-(1-Pyrrolidinyl)-1-p-tolypropenyl]pyridine trans-1-(2-Pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene trans-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine EINECS 207-627-0 Triprolidine Tripyrolidine 1t-[2]Pyridyl-3-pyrrolidino-1c-p-tolyl-propen (E)-1-(2-pyridyl)-3-pyrrolidin-1-yl-1-p-tolylpropene 1t-[2]pyridyl-3-pyrrolidino-1c-p-tolyl-propene (E)-2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]pyridine

Description	Triprolidine is an orally active H1R Antagonist antagonist. Triprolidine has the function of spinal cord motor and sensory block. Triprolidine can be used for the research of allergic rhinitis[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
In Vitro	Triprolidine (maturing human dendritic cells) can antagonist histamine H1 and decreases the expression of CD45[1].
In Vivo	Triprolidine (292.81-1467.20 μg/kg; i.p.; Male Sprague-Dawley rat) produces a dose-dependent effect of spinal motor and sensory block in rats[2]. Animal Model: Male Sprague-Dawley rat (300-350 g)[2] Dosage: 292.81, 488.02, 733.60, 1098.83 and 1467.20 μg/kg Administration: Intrathecal injection Result: Elicited spinal block in a dose-dependent.
References	[1]. Szeberényi JB, et, al. Inhibition of effects of endogenously synthesized histamine disturbs in vitro human dendritic cell differentiation. Immunol Lett. 2001 Apr 2;76(3):175-82. [2]. Tzeng JI, et, al. Spinal sensory and motor blockade by intrathecal doxylamine and triprolidine in rats. J Pharm Pharmacol. 2018 Dec;70(12):1654-1661. [3]. Deal DL, Chandrasurin P, Shockcor J, Minick DJ, Findlay JW, McNulty MJ. Disposition and metabolism of triprolidine in mice. Drug Metab Dispos. 1992 Nov-Dec;20(6):920-7.

Density	1.061 g/cm3
Boiling Point	435.4ºC at 760 mmHg
Melting Point	126-130°C
Molecular Formula	C₁₉H₂₂N₂
Molecular Weight	278.39100
Flash Point	217.1ºC
Exact Mass	278.17800
PSA	16.13000
LogP	3.85540
Vapour Pressure	6.16E-09mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT5812000

CHEMICAL NAME :: Pyridine, 2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)- , (E)-

CAS REGISTRY NUMBER :: 486-12-4

LAST UPDATED :: 199801

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H22-N2

MOLECULAR WEIGHT :: 278.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 143 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - alteration of operant conditioning Behavioral - changes in psychophysiological tests

REFERENCE :: EJCPAS European Journal of Clinical Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1970- Volume(issue)/page/year: 47,331,1994 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2700 mg/kg/90D-C

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of salivary glands Liver - fatty liver degeneration

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,96,1985

Safety Phrases	S36/37

70708-28-0 structure

70708-28-0

~82%

486-12-4 structure

486-12-4

Literature: HIKAL LIMITED Patent: WO2009/84035 A1, 2009 ; Location in patent: Page/Page column 5; 9-10 ;

Precursor 1
70708-28-0
DownStream 1
550-70-9