84449-90-1
84449-90-1 structure
- Name: Raloxifene
- Chemical Name: raloxifene
- CAS Number: 84449-90-1
- Molecular Formula: C28H27NO4S
- Molecular Weight: 473.583
- Catalog: API Antineoplastic agents Hormone antineoplastic agents
- Create Date: 2018-04-16 08:00:00
- Modify Date: 2024-01-02 12:26:37
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Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research[1].
| Name | raloxifene |
|---|---|
| Synonyms |
[2-(4-Hydroxyphenyl)-6-hydroxybenzo[b]thien-3-yl] [4-[2-(1-piperidinyl)ethoxy]phenyl]methanone
Raloxifeno [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidino-ethoxy)benzoyl]benzo[b]thiophene [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl][4-(2-piperidin-1-ylethoxy)phenyl]methanone [6-Hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]{4-[2-(1-piperidinyl)ethoxy]phenyl}methanone [6-Hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]{4-[2-(piperidin-1-yl)ethoxy]phenyl}methanone UNII-YX9162EO3I Raloxifenum [Latin] Raloxifene [INN:BAN] [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone Raloxifeno [Spanish] Keoxifene [3H]-Raloxifene MFCD00866415 Methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]- Methanone, (6-hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)- Raloxifene [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothien-3-yl]{4-[(2-piperidin-1-ylethyl)oxy]phenyl}methanone Raloxifenum [14C]-Raloxifene Raloxifene HCl |
| Description | Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research[1]. |
|---|---|
| Related Catalog | |
| Target |
Estrogen receptor |
| In Vivo | Raloxifene (4 mg/kg; intragastrically; daily for 13 weeks) significantly prevents bone loss in ovariectomized (OVX) rats[1]. Animal Model: Female, 12-week-old, Wistar rats (OVX rats)[1] Dosage: 4 mg/kg Administration: Intragastrically; daily for 13 weeks Result: Significantly increased the levels of E2 in OVX rats and significantly decreased the levels of BGP. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 728.2±60.0 °C at 760 mmHg |
| Melting Point | 250-253°C |
| Molecular Formula | C28H27NO4S |
| Molecular Weight | 473.583 |
| Flash Point | 394.2±32.9 °C |
| Exact Mass | 473.166077 |
| PSA | 98.24000 |
| LogP | 6.80 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.666 |
| Storage condition | Desiccate at +4°C |
| Water Solubility | DMSO: 28 mg/mL, soluble |
| WGK Germany | 3 |
|---|
| Precursor 8 | |
|---|---|
| DownStream 4 | |
![[6-[(methylsulfonyl)oxy]-2-[4-[(methylsulfonyl)oxy]phenyl]benzo[b]thien-3-yl][4-[2-(1-pyrrolidinyl)ethoxy]phenyl]methanone hydrochloride structure](https://www.chemsrc.com/caspic/336/84449-85-4.png)
![6-benzoyloxy-2-(4-benzoyloxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene, hydrochloride structure](https://www.chemsrc.com/caspic/412/84449-83-2.png)
![4-(6-((METHYLSULFONYL)OXY)BENZO[B]THIOPHEN-2-YL)PHENYL METHANESULFONATE structure](https://www.chemsrc.com/caspic/250/84449-65-0.png)
![[6-[tert-butyl(dimethyl)silyl]oxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone structure](https://www.chemsrc.com/caspic/159/174264-47-2.png)
