82248-59-7

82248-59-7 structure

Name: Atomoxetine Hydrochloride
Chemical Name: atomoxetine hydrochloride
CAS Number: 82248-59-7
Molecular Formula: C₁₇H₂₂ClNO
Molecular Weight: 291.816
Catalog: Biochemical Inhibitor Neuronal Signaling 5-HT Receptor Inhibitor
Create Date: 2018-08-12 17:52:29
Modify Date: 2024-01-01 23:33:57
Atomoxetine Hcl(LY 139603; Tomoxetine Hcl) is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). IC50 value: 5 nM (Ki for human NET)Target: NETAtomoxetine displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Atomoxetine is antidepressant and a commonly used non-stimulant treatment for Attention deficit hyperactivity disorder (ADHD).

Name	atomoxetine hydrochloride
Synonyms	Atomoxetine HCL benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, (γR)-, hydrochloride (gR)-N-Methyl-g-(2-methylphenoxy)benzenepropanamine Hydrochloride (3R)-N-méthyl-3-(2-méthylphénoxy)-3-phénylpropan-1-amine chlorhydrate MFCD06410992 (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride (1:1) Atomoxetine hydrochloride EINECS 200-659-6 (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine hydrochloride (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropan-1-aminhydrochlorid (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenyl-1-propanamine hydrochloride (1:1) Benzenepropanamine, N-methyl-γ-(2-methylphenoxy)-, (γR)-, hydrochloride (1:1) Atomoxetine (hydrochloride)

Description	Atomoxetine Hcl(LY 139603; Tomoxetine Hcl) is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5, 77 and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively). IC50 value: 5 nM (Ki for human NET)Target: NETAtomoxetine displays minimal affinity for a range of other neurotransmitter receptors and transporters (Ki > 1 μM). Atomoxetine is antidepressant and a commonly used non-stimulant treatment for Attention deficit hyperactivity disorder (ADHD).
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. McAfee AT, Landon J, Jones M, et al. A cohort study of the risk of seizures in a pediatric population treated with atomoxetine or stimulant medications. Pharmacoepidemiol Drug Saf. 2012 Dec 26. [2]. Turner M, Wilding E, Cassidy E, Dommett EJ. Effects of atomoxetine on locomotor activity and impulsivity in the spontaneously hypertensive rat. Behav Brain Res. 2012 Dec 22;243C:28-37. [3]. Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 N [4]. Owens MJ, Morgan WN, Plott SJ, Nemeroff CB. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. J Pharmacol Exp Ther. 1997 Dec;283(3):1305-22. [5]. Atomoxetine

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	F,T
Risk Phrases	11-23/24/25-39/23/24/25
Safety Phrases	S22-S24/25
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3
HS Code	2922299090

HS Code	2922299090
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%