CKS-17
Names
[ CAS No. ]:
99273-04-8
[ Name ]:
CKS-17
[Synonym ]:
1067: PN: US20090175821 SEQID: 1339 claimed protein
CKS-17
Biological Activity
[Description]:
CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has the highly conserved amino acid sequences occurring within the transmembrane envelope protein of many animal and human retroviruses. CKS-17 acts as an immunomodulatory epitope and exhibits suppressive properties for numerous immune functions[1][2][3].
[Related Catalog]:
[In Vitro]
CKS-17 (THP-1 cells) induces increased intracellular cAMP via activation of adenylate cyclase[1]. CKS-17 (15 μM; EL4 cells) inhibits interleukin-2 production by tumor cell products[3].
[In Vivo]
CKS-17 (10 μM; i.d.; B6AF1 mice and C57BL/6J mice) inhibits delayed-type hypersensitivity (DTH) reactions to sheep erythrocytes in the feet of mice[2]. Animal Model: B6AF1 mice and C57BL/6J mice with DTH models[2] Dosage: 10 μM Administration: Intradermal injection, into the right hind footpad Result: Had a transient depressive effect on DTH reaction.
Chemical & Physical Properties
[ Density]:
1.41±0.1 g/cm3 (20 °C, 760 mmHg)
[ Molecular Formula ]:
C87H148N26O24
[ Molecular Weight ]:
1942.27000
[ Exact Mass ]:
1941.12000
[ PSA ]:
839.52000
[ LogP ]:
5.14200