(2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane
Names
[ CAS No. ]:
98737-29-2
[ Name ]:
(2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane
[Synonym ]:
Carbamic acid, N-[(1S)-1-(2R)-2-oxiranyl-2-phenylethyl]-, 1,1-dimethylethyl ester
tert-Butyl {(1S)-1-[(2R)-oxiran-2-yl]-2-phenylethyl}carbamate
(2S,3S)-N-t-Boc-3-amino-1,2-epoxy-4-phenylbutane
tert-Butyl-{(1S)-1-[(2R)-oxiran-2-yl]-2-phenylethyl}carbamat
2-Methyl-2-propanyl {(1S)-1-[(2R)-2-oxiranyl]-2-phenylethyl}carbamate
Carbamic acid, N-[(1S)-1-[(2R)-oxiranyl]-2-phenylethyl]-, 1,1-dimethylethyl ester
T3OTJ BY1R&MVOX1&1&1 &&(1S)-(2R)- Form
MFCD02258997
EINECS 425-420-5
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
398.8±25.0 °C at 760 mmHg
[ Melting Point ]:
125-127ºC
[ Molecular Formula ]:
C15H21NO3
[ Molecular Weight ]:
263.332
[ Flash Point ]:
195.0±23.2 °C
[ Exact Mass ]:
263.152130
[ PSA ]:
50.86000
[ LogP ]:
3.44
[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C
[ Index of Refraction ]:
1.533
MSDS
Safety Information
[ Symbol ]:
GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H410
[ Precautionary Statements ]:
P273-P501
[ Hazard Codes ]:
F,Xi
[ Risk Phrases ]:
R10
[ Safety Phrases ]:
7/9-16-26-36/37/39
[ RIDADR ]:
UN 3077 9 / PGIII
[ WGK Germany ]:
3
Articles
J. Med. Chem. 49 , 5252, (2006)
Structure-based design and synthesis of novel HIV protease inhibitors are described. The inhibitors are designed specifically to interact with the backbone of HIV protease active site to combat drug r...
Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands.J. Med. Chem. 49 , 7342, (2006)
Here, we describe the design, synthesis, and biological evaluation of novel HIV-1 protease inhibitors incorporating N-phenyloxazolidinone-5-carboxamides into the (hydroxyethylamino)sulfonamide scaffol...
Probing pockets S2-S4' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimetics.Bioorg. Med. Chem. Lett. 14 , 1935-1938, (2004)
(Hydroxyethyl)urea peptidomimetics are potent inhibitors of gamma-secretase that are accessible in a few synthetic steps. Systematic alteration of P2-P4' revealed that the corresponding S2-S4' active ...