PF 750

Names

[ Name ]:
PF 750

[Synonym ]:
N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide
1-Piperidinecarboxamide, N-phenyl-4-(3-quinolinylmethyl)-
N-Phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide
PF-750
Nisoxetine hydrochloride

Biological Activity

[Description]:

PF 750 is a selective and covalent fatty acid amide hydrolase (FAAH) inhibitor, with IC50s varied from 16.2-595 nM in different pre-incubation times. Covalently modifies the enzyme’s active site serine nucleophile[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH

Research Areas >> Metabolic Disease

Signaling Pathways >> Neuronal Signaling >> FAAH

[Target]

IC50: 16.2-595 nM (FAAH)[1].

[References]

[1]. Ahn K, et al. Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry. 2007 Nov 13;46(45):13019-30.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
582.7±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₃N₃O

[ Molecular Weight ]:
345.438

[ Flash Point ]:
306.2±25.1 °C

[ Exact Mass ]:
345.184113

[ PSA ]:
45.23000

[ LogP ]:
3.77

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.672

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport