Tris(2,4-di-tert-butylphenyl)phosphate

Names

[ Name ]:
Tris(2,4-di-tert-butylphenyl)phosphate

[Synonym ]:
MFCD29918884

Biological Activity

[Description]:

Tris(2,4-di-tert-butylphenyl)phosphate is an active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A2 (sPLA2) through molecular docking[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

Research Areas >> Inflammation/Immunology

[Target]

sPLA2[1]

[In Vivo]

Tris(2,4-di-tert-butylphenyl)phosphate (TDTBPP; 50 mg/kg and 70 mg/kg) exhibits significant anti-inflammatory activity in carrageenan induced paw odema model[1]. Tris(2,4-di-tert-butylphenyl)phosphate (50 mg/kg and 70 mg/kg) reduces the raw paw odema volume significantly[1].

[References]

[1]. Vinuchakkaravarthy T, et al. Active compound from the leaves of Vitex negundo L. shows anti-inflammatory activity with evidence of inhibition for secretory Phospholipase A(2) through molecular docking. Bioinformation. 2011;7(4):199-206.

Chemical & Physical Properties

[ Melting Point ]:
99-101 °C(lit.)

[ Molecular Formula ]:
C₄₂H₆₃O₄P

[ Molecular Weight ]:
662.92100

[ Exact Mass ]:
662.44600

[ PSA ]:
54.57000

[ LogP ]:
13.11650

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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