(3S,5R)-Fluvastatin sodium

Names

[ Name ]:
(3S,5R)-Fluvastatin sodium

[Synonym ]:
(3S,5R)-Fluvastatin Sodium Salt
6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, monosodium salt, (3S,5R,6E)-
6-Heptenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-, monosodium salt, [R-[R*,S*-(E)]]-

Biological Activity

[Description]:

(3S,5R)-Fluvastatin sodium ((3S,5R)-XU 62-320) is the (3S,5R)-enantiomer of Fluvastatin. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> HMG-CoA Reductase (HMGCR)

[References]

[1]. Araújo FA, Rocha MA, Capettini LS, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS. 2012 24.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₅FNNaO₄

[ Molecular Weight ]:
434.45600

[ Exact Mass ]:
434.17400

[ PSA ]:
82.69000

[ LogP ]:
4.62810

Related Compounds

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