2-Ethoxybenzamide

Names

[ CAS No. ]:
938-73-8

[ Name ]:
2-Ethoxybenzamide

[Synonym ]:
2-Ethoxyphenylformamide
2-ethoxy-benzoic acid amide
Etamide
Ethosalicyl
Aethylaethersalicylsaeure-amid
Benzamide,2-ethoxy
2-Aethoxy-benzamid
EINECS 213-346-4
4-10-00-00175 (Beilstein Handbook Reference)
Pirosolvina
Ethenzamide
2-Ethoxybenzenecarbonamide
MFCD00007977
Phenetolcarbamide
Salicylamide o-Ethyl Ether
Benzamide, 2-ethoxy-
Etenzamide [DCIT]
2-Aethoxy-benzoesaeure-amid
Ethenzamide (JP15)
2-Ethoxybenzamide
o-Ethoxybenzamide
Etenzamide
Ethbenzamide
2-Ethoxybenzolcarboxamid
O-Aethyl-salicylamid

Biological Activity

[Description]:

2-Ethoxybenzamide is widely used as an antipyretic anodyne.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
302.0±25.0 °C at 760 mmHg

[ Melting Point ]:
129-134 °C

[ Molecular Formula ]:
C₉H₁₁NO₂

[ Molecular Weight ]:
165.189

[ Flash Point ]:
153.7±19.5 °C

[ Exact Mass ]:
165.078979

[ PSA ]:
52.32000

[ LogP ]:
1.40

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.538

[ Water Solubility ]:
<0.1 g/100 mL at 16 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV4900000

CHEMICAL NAME :: Benzamide, o-ethoxy-

CAS REGISTRY NUMBER :: 938-73-8

BEILSTEIN REFERENCE NO. :: 2208582

LAST UPDATED :: 199701

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C9-H11-N-O2

MOLECULAR WEIGHT :: 165.21

WISWESSER LINE NOTATION :: ZVR BO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2630 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Behavioral - sleep Cardiac - other changes Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 544 gm/kg/54W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors

TYPE OF TEST :: Morphological transformation

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 500 mg/L

REFERENCE :: ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (96),55,1978

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
CU4381000

[ HS Code ]:
29242995

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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