CB2 receptor agonist 3

Names

[ CAS No. ]:
919077-81-9

[ Name ]:
CB2 receptor agonist 3

[Synonym ]:
nor-Binaltorphimine dihydrochloride
HMS3269N05
N-Cyclohexyl-1-(2,4-dichlorophenyl)-6-methyl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide
GP 2A
Indeno[1,2-c]pyrazole-3-carboxamide, N-cyclohexyl-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methyl-

Biological Activity

[Description]:

CB2 receptor agonist 3 is a robust and selective CB2 cannabinoid agonist with Kis of 7.6 and 900 nM for CB2 and CB1, respectively. CB2 receptor agonist 3 significantly increases P-ERK 1/2 expression in HL-60 cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[In Vitro]

CB2 receptor agonist 3 (Compound 2a) is also shown to be agonist in an in vitro model based on human promyelocytic leukemia HL-60 cells[1].

[References]

[1]. Murineddu G, et al. Tricyclic pyrazoles. 4. Synthesis and biological evaluation of analogues of the robust and selective CB2 cannabinoid ligand 1-(2',4'-dichlorophenyl)-6-methyl-N-piperidin-1-yl-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide. J Med Chem. 2006;49(25):7502-7512.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
632.9±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₄H₂₃Cl₂N₃O

[ Molecular Weight ]:
440.365

[ Flash Point ]:
336.6±31.5 °C

[ Exact Mass ]:
439.121826

[ PSA ]:
46.92000

[ LogP ]:
6.58

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.700

Related Compounds

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