PSB 0474

Names

[ Name ]:
PSB 0474

[Synonym ]:
3-phenacyl udp disodium salt
psb 0474

Biological Activity

[Description]:

PSB 0474 (3-phenacyl-UDP) is a selective and potent P2Y6 receptor agonist with an EC50 of 70 nM[1]. PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis[2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Signaling Pathways >> GPCR/G Protein >> P2Y Receptor

Research Areas >> Neurological Disease

[Target]

IC50: 70 nM (P2Y6)[1]

[References]

[1]. Ali El-Tayeb, et al. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49(24):7076-87.

[2]. Clara Quintas, et al. Microglia P2Y₆ receptors mediate nitric oxide release and astrocyte apoptosis. J Neuroinflammation. 2014 Sep 3;11:141.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₀N₂O₁₃P₂

[ Molecular Weight ]:
522.29

[ Exact Mass ]:
566.00800

[ PSA ]:
249.33000

Related Compounds

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